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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-23-267: Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

    Release Date: 04-18-2023Open Date: 05-06-2023 Due Dates: Multiple Close Date: 06-07-2025

    Purpose This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support SBCs to propose the development of novel extracellular vesicle-based therape ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-23-268: Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (UT1/UT2) Clinical Trial Not Allowed

    Release Date: 04-18-2023Open Date: 05-06-2023 Due Dates: Multiple Close Date: 06-07-2025

    Purpose This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I and Phase II (Fast track) grant applications. The funding opportunity will utilize a UT1/UT2 cooperative agreement to support SBCs to propose the development of novel extracellular vesicle (EV)-based therapeutic platforms for ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. SOCOM244-006: Digital Projection Close Quarters Sight (DP-CQS)

    Release Date: 10-03-2023Open Date: 03-25-2024Due Date: 03-31-2025Close Date: 05-13-2025

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Microelectronics; Human-Machine Interfaces. The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), which controls the export and import of defense-related material and services. Offerors must disclose any proposed use of foreign nationals, their country of origin, and what tasks each would accomplish in ...

    SBIRPhase I/Phase IIDepartment of DefenseSpecial Operations Command
  4. DHA244-D001: Sample Collection and Processing Methods to Support Battlefield Wound Infection Diagnostics (Direct to Phase II)

    Release Date: 10-03-2023Open Date: 03-26-2024Due Date: 03-31-2025Close Date: 05-13-2025

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Military Infectious Disease OBJECTIVE: This topic is intended for technology proven ready to move directly into Phase II and is accepting Direct to Phase II proposals only. Develop a simple-to-use sample collection and processing method capable of preparing an adequate specimen for subsequent identification and accurate detection of specific fungal and/o ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  5. DHA244-D002: Innovative Solutions for Ethylene Oxide Mitigation Used in Sterilization Processes (Direct to Phase II)

    Release Date: 10-03-2023Open Date: 03-26-2024Due Date: 03-31-2025Close Date: 05-13-2025

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Combat Casualty Care OBJECTIVE: This topic is intended for technology proven ready to move directly into Phase II and is accepting Direct to Phase II proposals only. Develop innovative solutions that effectively mitigate ethylene oxide used as part of and generated during sterilization processes, promoting environmentally friendly and sustainable practic ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  6. DHA244-D003: Advanced Information Technology to Improve Mobility, Interoperability, and Survivability of Expeditionary Medical Command, Control, Communications, and Computers (Direct to Phase II)

    Release Date: 10-03-2023Open Date: 03-26-2024Due Date: 03-31-2025Close Date: 05-13-2025

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Combat Casualty Care OBJECTIVE: This topic is intended for technology proven ready to move directly into Phase II and is accepting Direct to Phase II proposals only. Develop expeditionary and interoperable information technology (IT) to enable health care delivery (HCD), medical command and control (MEDC2), medical logistics (MEDLOG), and patient movemen ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Health Agency
  7. PAR-23-220: SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1 Clinical Trial Required)

    Release Date: 07-12-2023Open Date: 08-05-2023 Due Dates: Multiple Close Date: 04-06-2025

    The NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies that benefit society. The main objective in SBIR/STTR Phase I is to establish the technical merit and feasibility of the proposed research and development (R&D) eff ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-23-219: SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)

    Release Date: 07-12-2023Open Date: 08-05-2023 Due Dates: Multiple Close Date: 04-06-2025

    The NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies that benefit society. The main objective in SBIR/STTR Phase I is to establish the technical merit and feasibility of the proposed research and development (R&D) eff ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. RFA-NS-23-006: HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)

    Release Date: 09-15-2022Open Date: 12-04-2022 Due Dates: Multiple Close Date: 04-05-2025

    Purpose The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Innovation Research (SBIR) program. Specifically, this FOA is focused on applications directed at improving pain measurement ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. RFA-NS-23-007: HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)

    Release Date: 09-15-2022Open Date: 12-04-2022 Due Dates: Multiple Close Date: 04-05-2025

    Purpose The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Technology Transfer (STTR) program. Specifically, this FOA is focused on applications directed at improving pain measurement ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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