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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-21-057: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

    Release Date: 11-19-2020Open Date: 01-22-2021 Due Dates: Multiple Close Date: 09-08-2023

    Background A biomarker is a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities are diverse, and can include ‘omics, imaging, behavioral, digital and physiologic endpoints, as well as composite biomarkers or biomarker signatures. Becaus ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. HC1: Analytics

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    HC1 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  3. BT1: Animal Biotechnology

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    BT1 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  4. AF212-D003: Applications of AI/ML Pitch Day for Trusted Artificial Intelligence

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Cybersecurity; Artificial Intelligence/Machine Learning TECHNOLOGY AREAS: Information Systems OBJECTIVE: The objective of this topic is to apply existing AI/ML solutions to operational Air Force problems. This topic will reach companies that can complete a feasibility study and prototype validated concepts in accelerated Phase II schedules. This topic is specifically aimed at l ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  5. AI: Artificial Intelligence (AI)

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    The Artificial Intelligence topic focuses on innovations in the field of artificial intelligence (AI), which refers to intelligence exhibited by machines or software. AI is not a specific technology or technical method – it is instead a field of study aimed at achieving machine-based intelligence. These subtopic areas are meant to serve as examples; all proposals with technical innovation and si ...

    SBIRPhase INational Science Foundation
  6. AF212-0002: Artificial Intelligence Tool for Background Database Generation

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Artificial Intelligence/Machine Learning; General Warfighting Requirements (GWR) TECHNOLOGY AREAS: Sensors; Space Platform; Air Platform; Battlespace OBJECTIVE: Scene Generation tools are used to create synthetic image data representative of what a sensor on a weapon system would measure. Creating synthetic data is limited by lack of available models or lack of measured datab ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  7. AF212-0011: ASCENT Based Thruster Component and System Characterization and Optimization for Lifetime Extension

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Network Command, Control and Communications TECHNOLOGY AREAS: Space Platform OBJECTIVE: Mature advanced spacecraft energetic non-toxic (ASCENT), formerly referred to as AF-M315E, technology to meet or exceed the performance of state of the art chemical propulsion systems for air and space platforms requiring thrust levels from 1 N through 44.5 kN. DESCRIPTION: The intent of ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  8. AF212-D002: Assurance of Trusted AI/ML Systems Pitch Day for Trusted AI

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Cybersecurity; Artificial Intelligence/Machine Learning TECHNOLOGY AREAS: Information Systems OBJECTIVE: The objective of this topic is to explore the design of tools, techniques and methods necessary to support the development of trusted AI systems at speed and scale within modern development pipelines. DESCRIPTION: A key element of trust in AI is our ability to impart and as ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  9. LC1: Asynchronous and Remote Learning

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    LC1 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  10. AV1: Audio Augmentation and Interfaces

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    AV1 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
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