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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-DA-25-052: Tools for decentralized clinical trials for substance use disorder (R43/R44 Clinical Trials Optional)

    Release Date: 10-25-2023Open Date: 02-14-2024Due Date: 03-14-2024Close Date: 03-15-2024

    Substance use disorder (SUD) clinical trials traditionally perform recruitment, enrollment, interventions, as well as information collection at the clinical trial sites. In-person visits at the sites are used for screening, assignment to interventions, treatment or other intervention, follow up, as well as collection of information from participants and entering it in a database. Some of the in-p ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-24-063: Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 11-01-2023Open Date: 01-09-2024 Due Dates: Multiple Close Date: 08-19-2026

    Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food and Drug Admin ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. 8.1: Forests and Related Resources

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Forests and Related Resources topic area aims to address the health, diversity, and productivity of the Nation’s forests to meet the needs of present and future generations through the development of environmentally sound approaches to increase productivity of forest lands, improve sustainability and develop value-added materials derived from forest resources.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  4. 8.2: Plant Production and Protection – Biology

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The objective of this topic area is to develop novel ways of enhancing crop production and protection against abiotic and/or biotic stresses through the use of novel diagnostic technologies, plant improvement approaches, and tools or management practices that ensure healthy pollinators.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  5. 8.3: Animal Production and Protection

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Animal Production and Protection topic area aims to develop innovative, marketable technologies that will provide significant benefit to the production and protection of agricultural animals.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  6. 8.4: Conservation of Natural Resources

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Conservation of Natural Resources topic area aims to develop innovative technologies that are developed with the purpose to conserve, monitor, improve and/or protect the quality and/or quantity of natural resources while sustaining optimal farm and forest productivity and profitability. We encourage new technologies and innovations that will help improve soil health, reduce soil erosion, impro ...

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  7. 8.5: Food Science and Nutrition

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Food Science and Nutrition topic area aims to fund projects that support research focusing on developing new and improved processes, technologies, or services that address emerging food safety, food processing, and nutrition issues.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  8. 8.6: Rural and Community Development

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Rural and Community Development topic area aims to fund the development of new technologies, or for the utilization of existing technologies, that address important economic and social development issues or challenges in rural America. The applications need not be centered on agriculture but may be focused on any area that has the potential to provide significant benefit to rural Americans.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  9. 8.7: Aquaculture

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Aquaculture topic area aims to develop new technologies that will enhance the knowledge and technology base necessary for the expansion of the domestic aquaculture industry as a form of production agriculture.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  10. 8.8: Biofuels and Biobased Products

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The objective of this topic area is to promote the use of biofuels and non-food biobased products by developing new or improved technologies that will lead to increased production of biofuels, industrial chemicals, and other value-added products from agricultural materials.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
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