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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. 8.5: Food Science and Nutrition

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Food Science and Nutrition topic area aims to fund projects that support research focusing on developing new and improved processes, technologies, or services that address emerging food safety, food processing, and nutrition issues.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  2. 8.6: Rural and Community Development

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Rural Development topic area aims to fund the development of new technology, or for the utilization of existing technology, that address important economic and social development issues or challenges in rural America. The applications need not be centered on agriculture but may be focused on any area that has the potential to provide significant benefit to rural Americans.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  3. 8.7: Aquaculture

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Aquaculture topic area aims to develop new technologies that will enhance the knowledge and technology base necessary for the expansion of the domestic aquaculture industry as a form of production agriculture.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  4. 8.8: Biofuels and Biobased Products

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The objective of this topic area is to promote the use of biofuels and non-food biobased products by developing new or improved technologies that will lead to increased production of biofuels, industrial chemicals, and other value-added products from agricultural materials.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  5. 8.12: Small and Mid-Size Farms

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The Small and Mid-Size Farms topic area aims to promote and improve the sustainability and profitability of small and mid-size farms and ranches (where annual sales of agricultural products are less than $250,000 for small farms and $500,000 for mid-size farms).

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  6. 8.13: Plant Production and Protection- Engineering

    Release Date: 12-28-2020Open Date: 12-28-2020Due Date: 05-03-2021Close Date: 05-03-2021

    The objective of this topic area is to enhance crop production by creating and commercializing engineering technologies that enhance system efficiency and profitability and protect crops from pests and pathogens in economically and environmentally sound ways.

    SBIRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  7. HHS-2021-ACL-NIDILRR-BISB-0026: Small Business Innovation Research Program (SBIR) Phase II Department of Health and Human Services Administration for Community Living

    Release Date: 03-30-2021Open Date: 03-30-2021Due Date: 06-01-2021Close Date: 06-01-2021

    SBIR Phase I grantees who successfully completed their Phase I grant in fiscal year 2019, 2020 or 2021 are eligible to apply. These eligible applicants only include (1) Phase I grantees who successfully completed their Phase I work within the past 3 years (2019, 2020, 2021) with Phase I funding from NIDILRR, or (2) Phase I grantees who successfully completed with Phase I work within the past 3 yea ...

    SBIRPhase IIDepartment of Health and Human ServicesAdministration for Community Living
  8. RFA-MD-21-006: Innovations for Healthy Living- Improving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

    Release Date: 03-11-2021Open Date: 04-05-2021Due Date: 05-03-2021Close Date: 05-04-2021

    Background Over the years, there has been continued improvement of health for Americans with the introduction of medical and scientific advances. Despite notable health improvements for the population as a whole through technological advancement, there continues to be an alarming disproportionate burden of illness among persons from racial and ethnic minority and other population groups who exper ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-20-098: Non-Viral Technologies for in vivo Delivery of Genome Editors (R43/R44 Clinical Trial Not Allowed)

    Release Date: 02-06-2020Open Date: 03-05-2020 Due Dates: Multiple Close Date: 01-06-2022

    Research Objectives Maximizing the therapeutic impact of somatic genome editing requires the development of safe and effective technologies to deliver genome editing machinery into all disease-relevant somatic cells and tissues. Therefore, the objective of this FOA is to support the development and evaluation of innovative approaches to deliver genome editing machinery into somatic cells, with th ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PA-20-047: Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 01-08-2020Open Date: 03-05-2020 Due Dates: Multiple Close Date: 01-06-2023

    Background Single cell analysis has recently become an active area of research to uncover fundamental biological principles behind cell diversity, which are often masked and not amenable to the population analysis of cells. The past several years have witnessed a rapid advancement in the development of single cell technologies and analysis methods. Multiple single cell "-omics" approaches are eme ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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