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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. CBD212-002: Augmented Reality CBRN Threat Display for Mounted Situational Awareness

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    KEY TECHNOLOGY AREA(S): Chemical/Biological Defense; Information Systems Technology; Human Systems OBJECTIVE: To provide a real-time, geospatially accurate, augmented reality display of various CBRNE sensor data to mounted and dismounted warfighters. DESCRIPTION: CBRN (Chemical, Biological, Radiological, Nuclear) sensors are present throughout the armed forces. The Stryker Nuclear Biological Che ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice for Chemical and Biological Defense
  2. MDA21-002: Automated MAP Compliance Assessment Tool

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Artificial Intelligence/ Machine Learning TECHNOLOGY AREA(S): Information Systems; Ground Sea; Weapons OBJECTIVE: Design, develop, and integrate a software audit tool that can be run in parallel with a software development environment and be able to identify when a software developer is or is not developing their software in accordance with MDA Assurance Provisions (MAP) requ ...

    SBIRPhase I/Phase IIDepartment of DefenseMissile Defense Agency
  3. MDA21-003: Automated System Architecture Tool

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Artificial Intelligence/ Machine Learning TECHNOLOGY AREA(S): Ground Sea; Weapons OBJECTIVE: Develop an automated tool that can import specifications and interface requirements from the specifications, DOORS modules, or spreadsheets and create a system architecture in Systems Modeling Language (SysML) or Unified Modeling Language (UML). DESCRIPTION: Some legacy missile defen ...

    SBIRPhase I/Phase IIDepartment of DefenseMissile Defense Agency
  4. DLA212-006: Automation-Robotics to support/supplement Dining Facilities

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Autonomy; Artificial Intelligence/ Machine Learning; General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Logistics Agency
  5. RFA-TR-21-010: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 01-13-2021Open Date: 03-13-2021 Due Dates: Multiple Close Date: 01-13-2022

    A. Overview While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underly multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molecu ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. AF212-D005: Behavioral Models, Methods & Metrics for Trust Establishment, Maintenance, and Repair in Human-Machine Co-Training Pitch Day for Trusted AI

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Autonomy; Artificial Intelligence/Machine Learning TECHNOLOGY AREAS: Information Systems; Battlespace OBJECTIVE: The objective of this topic is to explore the development of simultaneously training humans and machine partners to facilitate the establishment of trust, its maintenance, and its repair when failures occur. In particular, the proposed solutions should present some e ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  7. PAR-21-233: Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 04-23-2021Open Date: 07-10-2021 Due Dates: Multiple Close Date: 04-06-2024

    A. Overview Recent advances in biology offer unprecedented opportunities to discover new treatments for nervous system disorders. Biotherapeutic development, however, has inherent complexities with regards to characterization, manufacturing, delivery, and administration. Many academic laboratories and small business enterprises don’t have the full scope of expertise and resources available; thi ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-20-111: Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 03-02-2020Open Date: 07-11-2020 Due Dates: Multiple Close Date: 05-08-2023

    A. Overview Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food a ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. N212-101: Broadband Counter-Electronics Weapon (BCEW) for Long-Range Non-Lethal Vehicle/Vessel Stopping Capabilities

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Autonomy;Directed Energy (DE);Microelectronics TECHNOLOGY AREA(S): Weapons The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
  10. N212-122: Characterizing 5G vulnerabilities in an expeditionary environment

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): 5G;Cybersecurity TECHNOLOGY AREA(S): Information Systems The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
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