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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-NS-21-022: Translational Neural Devices (U44 Clinical Trial Optional)

    Release Date: 04-28-2021Open Date: 06-01-2021 Due Dates: Multiple Close Date: 02-21-2024

    A. Purpose The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical saf ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-21-082: NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)

    Release Date: 01-14-2021Open Date: 04-14-2021 Due Dates: Multiple Close Date: 01-15-2024

    Purpose This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials, including mechanistic studies associated with clinical trials. A clinical trial is defined by NIH as: "A research study in which one or more human subjects are prospectivel ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-21-114: NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44 Clinical Trial Not Allowed)

    Release Date: 01-25-2021Open Date: 03-05-2021 Due Dates: Multiple Close Date: 01-06-2024

    Purpose NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treat ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. DoD 23.D STTR Annual BAA: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 11-15-2022Open Date: 11-15-2022Due Date: 12-31-2023Close Date: 12-31-2023

    Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://www.defensesbirsttr.mil/ for specific topic open and close dates as well as BAA documents and instructions.

    STTRPhase IDepartment of Defense
  5. DoD 23.4 SBIR Annual BAA: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 11-15-2022Open Date: 11-15-2022Due Date: 12-31-2023Close Date: 12-31-2023

    Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://www.defensesbirsttr.mil/ for specific topic open and close dates as well as BAA documents and instructions.

    SBIRPhase I/Phase IIDepartment of Defense
  6. PAR-21-297: Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R43/R44 Clinical Trial Not Allowed)

    Release Date: 08-31-2021Open Date: 11-09-2021 Due Dates: Multiple Close Date: 12-10-2023

    The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokinetic (PK) ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PAR-21-298: Multipurpose Prevention Technology: Novel Systemic Options for Young Adults (R41/R42 Clinical Trial Not Allowed)

    Release Date: 08-31-2021Open Date: 11-09-2021 Due Dates: Multiple Close Date: 12-10-2023

    Purpose The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokin ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. AA: Advanced Analytics (AA)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Advanced Analytics topic focuses on innovations that involve the mathematical or computational analysis of data or statistics. This topic does not include learning-based systems, which are covered under the Artificial Intelligence (AI) topic. These subtopic areas are meant to serve as examples; all proposals with technical innovation and significant commercial potential are welcome, regardless ...

    SBIR/STTRPhase INational Science Foundation
  9. M: Advanced Manufacturing (M)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Advanced Manufacturing topic aims to support emerging innovations in manufacturing with the potential to stimulate the nation’s manufacturing sector by improving its efficiency, competitiveness, and sustainability. Proposed technology should be environmentally friendly, compatible with human health and planet health, and driven by technological advancements. Examples include, but are not lim ...

    SBIR/STTRPhase INational Science Foundation
  10. AM: Advanced Materials (AM)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Advanced Materials topic addresses the development of new and improved materials for a wide variety of commercial and industrial applications. Proposals may focus on the creation of innovative material systems and/or on critical fabrication, processing, or manufacturing challenges involved in the successful demonstration and commercialization of novel advanced materials. A broad range of appli ...

    SBIR/STTRPhase INational Science Foundation
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