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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.
If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).
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AF23C-T001: Data-Centric AI in Multi Domain Awareness
Release Date: 08-23-2023Open Date: 09-20-2023Due Date: 10-18-2023Close Date: 10-18-2023OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which con ...
STTRPhase IDepartment of DefenseAir Force -
AF233-0032: Design AF DCGS Next Gen Enterprise IT systems using 5G Technology for Low to Zero Maintenance
Release Date: 08-23-2023Open Date: 09-20-2023Due Date: 10-18-2023Close Date: 10-18-2023OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy;Integrated Network System-of-Systems;Advanced Computing and Software;Integrated Sensing and Cyber;Microelectronics OBJECTIVE: Design AF DCGS Next Gen Enterprise IT systems using 5G Technology for Low to Zero Maintenance DESCRIPTION: The DCGS Next Generation (DCGS Next Gen) delivers a new advantage to the Air Force and its Airmen. Du ...
SBIRPhase I/Phase IIDepartment of DefenseAir Force -
RFA-DA-23-021: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44- Clinical Trial Optional)
Release Date: 03-28-2022Open Date: 07-15-2022 Due Dates: Multiple Close Date: 02-15-2025According to the Centers for Disease Control and Prevention (CDC), more than 100,000 deaths from overdose were reported from April 2020 to April 2021 alone. Data shows an increase in overdoses due to natural and semi-synthetic opioids, synthetic opioids, predominantly fentanyl, and psychostimulants, such as methamphetamine or cocaine. In fact, in the year ending in April 2021, fentanyl was the lea ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health -
NIH/NIAID 133: Development of a Serological Test for Herpes Simplex Types 1 and 2 Infections
Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023(Direct to Phase II proposals will not be accepted) (Fast-Track proposals will be accepted) Number of anticipated awards: 1-2 Budget (total costs): Phase I: $300,000 for up to 1 year; Phase II: $1,500,000 for up to 3 years Page 118 Background Over 60 million people in the U.S. have genital herpes which is caused by infection with herpes simplex virus type 1 or 2 (HSV-1, HSV-2). The WHO’s 2021 gl ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health -
NIH/NIAID 131: Development of Bacteriophage for Treatment of Mycobacterial Infections
Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023Fast-Track proposals will be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 2-3 Budget (total costs): Phase I: $300,000 for up to one year; Phase II: $1,500,000 for up to 3 years Background There is an urgent need for new therapeutics products for treating pulmonary diseases caused by mycobacteria. These include tuberculosis (TB), caused by Mycobacterium ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health -
NIH/NIAID 125: Development of Long-Acting Treatments for HCV Cure
Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023Phase I and Fast Track proposals will be accepted Direct-to-Phase II proposals will not be accepted Number of anticipated awards: 2-3 Budget (total costs): Phase I: $ 300,000 for up to 2 years Phase II: $ 1 million for up to 3 years. Page 105 Background Globally, an estimated 58 million people have chronic hepatitis C virus (HCV) infection, with about 1.5 million new cases occurring per year. Amon ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health -
AF233-D013: Development of New Oxidation Resistant Refractory Alloys for Additively Manufactured (AM) Components
Release Date: 08-23-2023Open Date: 09-20-2023Due Date: 10-18-2023Close Date: 10-18-2023OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Computing and Software;Space Technology;Advanced Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regula ...
SBIRPhase I/Phase IIDepartment of DefenseAir Force -
NIH/NIAID 124: Development of Next-Generation Devices and Materials-Based Platforms for the Administration of HIV1 Broadly Neutralizing Antibodies
Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023Fast Track Proposals will be accepted. Direct-to-Phase II will not be accepted. Number of anticipated awards: 1-3 Budget (total costs): Phase I: $ 300,000 for up to 1 year. Phase II: $ 2 million for up to 3 years. Background Passive immunization by antibody administration has been used to prevent and/or treat several infectious diseases, including RSV, hepatitis A and B, rabies, and COVID-19. The ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health -
NIH/NIMH 002: Development of novel In-vitro and In-vivo Models to support NeuroHIV Research
Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023(Fast-Track and Direct to Phase 2 proposals will not be accepted) Number of anticipated awards: 1-3 Budget (total costs): Phase I: $300,000 for up to 1 year; Phase II: $2,000,000 for up to 2 years. Background Central Nervous System complications associated with HIV continues to persist in people with HIV (PWH) despite effective Page 128 Antiretroviral therapy (ART). Although excellent virologic co ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health -
CDC/NCEZID 031: Development of SHERLOCK Assay for Detection of High Threat Orthopoxviruses
Release Date: 08-25-2023Open Date: 08-25-2023Due Date: 11-14-2023Close Date: 11-14-2023Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I up to $243,500 for up to 6 months; Phase II of up to $1,927,828 and a Phase II duration of up to 2 years. PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Point ...
SBIRPhase I/Phase IIDepartment of Health and Human ServicesCenters for Disease Control and Prevention