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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. MD21-014: Optimized Waveforms for X-Band Missile-Defense Radars

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Microelectronics TECHNOLOGY AREA(S): Sensors; Electronics The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774 ...

    SBIRPhase I/Phase IIDepartment of DefenseMissile Defense Agency
  2. NGA212-001: Optical Shutter for Dynamic Active Electro-Optical Range Gating Systems

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Sensors, Electronics, and Electronic Warfare TECHNOLOGY AREA(S): Microelectronics, Space, GWR OBJECTIVE: Develop a compact, free-space electro-optical (EO) shutter to regulate photons arriving at a laser-based remote sensing receiver and to detect weak returns from targets largely obscured by strong returns from overhead tree canopies or camouflage. DESCRIPTION: The governme ...

    SBIRPhase I/Phase IIDepartment of DefenseNational Geospatial-Intelligence Agency
  3. MDA21-008: Operational Defense Effectiveness Assessments for Missile Raid Scenarios

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Artificial Intelligence/ Machine Learning TECHNOLOGY AREA(S): Information Systems OBJECTIVE: Develop a methodology and computer system that allows analysts to create and display operational defense effectiveness assessments for missile raid scenarios. DESCRIPTION: This topic seeks development of efficient solution techniques to perform operational defense effectiveness asses ...

    SBIRPhase I/Phase IIDepartment of DefenseMissile Defense Agency
  4. PA-18-708 : Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R43/R44 Clinical Trial Not Allowed)

    Release Date: 03-15-2018Open Date: 08-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background G-protein coupled receptor proteins (GPCRs) are membrane bound proteins that serve to modulate cellular activities. Many of the GPCRs have potential significance in healthy mental function and in mental disorders, including receptors for most neurotransmitters and neuropeptides. Drugs targeting GPCRs are currently used in the treatment of mental disorders such as schizophrenia, anxie ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. RFA-HG-20-016 : Novel Synthetic Nucleic Acid Technology Development (R43/R44) (Clinical Trial Not Allowed)

    Release Date: 03-19-2020Open Date: 03-25-2020 Due Dates: Multiple Close Date: 06-24-2022

    Purpose This Funding Opportunity Announcement (FOA) solicits R43/R44 grant applications to develop novel technologies that will enable no less than one order of magnitude improvement in commercial synthetic nucleic acid synthesis and constructs. Advances in genomics and more broadly in biomedical research have been greatly facilitated by significant and sustained synthetic nucleic acid increased ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. N212-107: Novel Feedstock Production System for Metallic Additive Manufactured Structural Parts and Repairs

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Air Platforms;Materials / Processes;Weapons OBJECTIVE: Develop a novel low-cost, high-yield metallic-powder production system capable of rapidly producing small batches (i.e., tens of grams to hundreds of kilograms) of feedstock for Additive Manufactured (AM) structural parts and repairs. DESCRIPTION: Current product ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
  7. PA-19-043: Novel Approaches for Relating Genetic Variation to Function and Disease (R43/R44 Clinical Trial Not Allowed)

    Release Date: 10-31-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Section I. Funding Opportunity Description Background Sequencing studies, including the 1000 Genomes Project and many disease studies, have identified more than 100 million sites in the human genome that vary among people. However, it is likely that most of the variants do not contribute to differences in function, traits, disease risk, or clinical outcomes. Thus, methods to determine which ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-20-098: Non-Viral Technologies for in vivo Delivery of Genome Editors (R43/R44 Clinical Trial Not Allowed)

    Release Date: 02-06-2020Open Date: 03-05-2020 Due Dates: Multiple Close Date: 01-06-2022

    Research Objectives Maximizing the therapeutic impact of somatic genome editing requires the development of safe and effective technologies to deliver genome editing machinery into all disease-relevant somatic cells and tissues. Therefore, the objective of this FOA is to support the development and evaluation of innovative approaches to deliver genome editing machinery into somatic cells, with th ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-21-114: NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44 Clinical Trial Not Allowed)

    Release Date: 01-25-2021Open Date: 03-05-2021 Due Dates: Multiple Close Date: 01-06-2024

    Purpose NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treat ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PAR-21-082: NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)

    Release Date: 01-14-2021Open Date: 04-14-2021 Due Dates: Multiple Close Date: 01-15-2024

    Purpose This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials, including mechanistic studies associated with clinical trials. A clinical trial is defined by NIH as: "A research study in which one or more human subjects are prospectivel ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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