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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PA-19-033 : Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R41/R42 Clinical Trial Not Allowed)

    Release Date: 10-24-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background The human genome has revealed a great deal about the human proteome, though significant portions remain understudied. Only a subset of expressed proteins demonstrates the requisite properties to serve as targets for the development of therapeutics. Many bona fide drug targets likely remain to be discovered in the "Druggable Genome" (DG), which can be defined as a subset of the ~20,000 ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PA-19-034 : Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 10-24-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background The human genome has revealed a great deal about the human proteome, though significant portions remain understudied. Only a subset of expressed proteins demonstrates the requisite properties to serve as targets for the development of therapeutics. Many bona fide drug targets likely remain to be discovered in the "Druggable Genome" (DG), which can be defined as a subset of the ~20,000 ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. N212-129: Components for a Deep Operating Unmanned Underwater Vehicle

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Microelectronics;Networked C3 TECHNOLOGY AREA(S): Battlespace Environments;Electronics;Ground / Sea Vehicles The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Ad ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
  4. PAR-19-061 : Computational Genomics and Data Science Opportunities for Small Business (R43/R44 Clinical Trial Not Allowed)

    Release Date: 11-09-2018Open Date: 12-05-2018 Due Dates: Multiple Close Date: 09-05-2021

    Background Since its inception the field of genomics has been grounded in computational approaches. All facets of genomic research, such as processing raw sequencing signals, assembling genomes, calling variants, deriving insight from population sequencing studies, and designing and studying the implementation of genomics in clinical settings, are dependent upon computational, analytical, statist ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. MDA21-019: Contextual Reasoning for Threat Classification Refinement

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Artificial Intelligence/ Machine Learning TECHNOLOGY AREA(S): Air Platform; Information Systems; Weapons The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Admini ...

    SBIRPhase I/Phase IIDepartment of DefenseMissile Defense Agency
  6. AF212-D007: 3D EO/SAR Reconstructions from Single and Limited Viewing Perspectives

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Autonomy; Artificial Intelligence/Machine Learning TECHNOLOGY AREAS: Sensors; Space Platform; Air Platform OBJECTIVE: Improve three-dimensional electro optical/synthetic aperture radar (3D EO/SAR) reconstructions of both single objects of interest and 3D scenes from limited 2D input images at varying viewing perspectives from airborne and/or space borne EO and SAR sensors for s ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  7. MDA21-013: Design Innovative Equipment to Produce Large Single-Crystal CdZnTe for Long-wave Infrared Detector Arrays

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Space; Microelectronics TECHNOLOGY AREA(S): Materials; Sensors; Electronics; Space Platform; Weapons The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administra ...

    SBIRPhase I/Phase IIDepartment of DefenseMissile Defense Agency
  8. AF212-0009: Design Tool for Multiple Electromagnetic Radome Problems

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    TECH FOCUS AREAS: Microelectronics; General Warfighting Requirements (GWR) TECHNOLOGY AREAS: Sensors; Materials; Information Systems OBJECTIVE: Develop a software tool for designing next generation military radomes that accounts for all aspects of the radome performance. DESCRIPTION: Modern military radomes have many electromagnetic requirements. A holistic approach must be taken when design ...

    SBIRPhase I/Phase IIDepartment of DefenseAir Force
  9. CBD212-004: Development and Testing of a Multi-dose Vial for Scopolamine Hydrobromide Trihydrate Formulation for Intramuscular Injection

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    KEY TECHNOLOGY AREAS: Chemical/Biological Defense, Biomedical OBJECTIVE: To develop a multi-dose, scopolamine hydrobromide trihydrate vial containing a formulation that is stable, injectable, and suitable for GMP manufacture. DESCRIPTION: The Joint Project Manager for Chemical, Biological, Radiological, and Nuclear Medical (JPM CBRN Medical) is developing scopolamine hydrobromide trihyd ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice for Chemical and Biological Defense
  10. N212-135: Development of a Widely Applicable Supporting Optical Circuit in Micro Optics

    Release Date: 04-21-2021Open Date: 05-19-2021Due Date: 06-17-2021Close Date: 06-17-2021

    RT&L FOCUS AREA(S): Hypersonics;Microelectronics TECHNOLOGY AREA(S): Battlespace Environments;Electronics;Weapons The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Re ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
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