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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-NS-23-007: HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)

    Release Date: 09-15-2022Open Date: 12-04-2022 Due Dates: Multiple Close Date: 04-05-2025

    Purpose The purpose of this Funding Opportunity Announcement (FOA) aims to speed scientific solutions to stem the national opioid public health crisis by supporting the development of therapies and technologies directed at enhanced pain management through the Small Business Technology Transfer (STTR) program. Specifically, this FOA is focused on applications directed at improving pain measurement ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. RFA-TR-22-032: Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44- Clinical Trail Not Allowed)

    Release Date: 09-19-2022Open Date: 10-21-2022 Due Dates: Multiple Close Date: 08-22-2023

    Section I. Funding Opportunity Description This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR)Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support small business concerns (SBCs) to propose a ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-23-032: Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)

    Release Date: 10-27-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-05-2025

    Purpose This Funding Opportunity Announcement (FOA) encourages the translation of technology and therapeutic innovations from academic and other non-profit research sectors to the marketplace to advance the development of diagnostic and prevention tools or treatments for musculoskeletal, rheumatic, or skin diseases. Small Business Concerns (SBCs) are encouraged to apply for this Small Business In ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. DoD 23.D STTR Annual BAA: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 11-15-2022Open Date: 11-15-2022Due Date: 12-31-2023Close Date: 12-31-2023

    Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://www.defensesbirsttr.mil/ for specific topic open and close dates as well as BAA documents and instructions.

    STTRPhase IDepartment of Defense
  5. DoD 23.4 SBIR Annual BAA: Various Topics with Varying Open and Close Dates- See Description for Links

    Release Date: 11-15-2022Open Date: 11-15-2022Due Date: 12-31-2023Close Date: 12-31-2023

    Annual BAA topics are released throughout the year with varying open and close dates. Please visit https://www.dodsbirsttr.mil/topics-app/ and https://www.defensesbirsttr.mil/ for specific topic open and close dates as well as BAA documents and instructions.

    SBIRPhase I/Phase IIDepartment of Defense
  6. AA: Advanced Analytics (AA)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Advanced Analytics topic focuses on innovations that involve the mathematical or computational analysis of data or statistics. This topic does not include learning-based systems, which are covered under the Artificial Intelligence (AI) topic. These subtopic areas are meant to serve as examples; all proposals with technical innovation and significant commercial potential are welcome, regardless ...

    SBIR/STTRPhase INational Science Foundation
  7. M: Advanced Manufacturing (M)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Advanced Manufacturing topic aims to support emerging innovations in manufacturing with the potential to stimulate the nation’s manufacturing sector by improving its efficiency, competitiveness, and sustainability. Proposed technology should be environmentally friendly, compatible with human health and planet health, and driven by technological advancements. Examples include, but are not lim ...

    SBIR/STTRPhase INational Science Foundation
  8. AM: Advanced Materials (AM)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Advanced Materials topic addresses the development of new and improved materials for a wide variety of commercial and industrial applications. Proposals may focus on the creation of innovative material systems and/or on critical fabrication, processing, or manufacturing challenges involved in the successful demonstration and commercialization of novel advanced materials. A broad range of appli ...

    SBIR/STTRPhase INational Science Foundation
  9. AI: Artificial Intelligence (AI)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Artificial Intelligence topic focuses on innovations in the field of artificial intelligence (AI), which refers to intelligence exhibited by machines or software. AI is not a specific technology or technical method – it is instead a field of study aimed at achieving machine-based intelligence. These subtopic areas are meant to serve as examples; all proposals with technical innovation and si ...

    SBIR/STTRPhase INational Science Foundation
  10. AV: Augmented and Virtual Reality (AV)

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    The Augmented and Virtual Reality topic aims to support the early-stage development of technological innovations in the hardware, software, photonics, displays, communication processes and other enabling technologies. Additionally, innovations that bring evidence-based academic discoveries to the public sphere via augmented and virtual reality technologies are also appropriate. Since augmented and ...

    SBIR/STTRPhase INational Science Foundation
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