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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. A244-032: High-Power Single Mode Diode Bars

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Sensing and Cyber; Directed Energy (DE); OBJECTIVE: Develop a diode bar with multi-watt (5-10W) power output per emitter that maintains single mode operation when coupled to an external wavelength beam combiner. DESCRIPTION: This topic seeks to enable power scaling in direct diode high energy lasers (HELs) while maintaining single mode ope ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  2. PAR-24-158: https://grants.nih.gov/grants/guide/PA-files/PAR-24-158.html

    Release Date: 02-29-2024Open Date: 03-05-2024 Due Dates: Multiple Close Date: 01-06-2027

    Introduction The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH), works to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. Translation is the process of turning observations in the ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. A244-P038: Hybrid Electric Powertrain, Power, and Propulsion Systems (HEPPS) Open Topic

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 09-16-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Materials; Advanced Computing and Software OBJECTIVE: The purpose of the Hybrid Electric Powertrain, Power, and Propulsion Systems (HEPPS) Open Topic is to bring potentially valuable small business innovations to the Army and create an opportunity to expand the relevance of the Army SBIR program to firms who do not normally compete for SBIR awar ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  4. PAR-23-268: Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (UT1/UT2) Clinical Trial Not Allowed

    Release Date: 04-18-2023Open Date: 05-06-2023 Due Dates: Multiple Close Date: 06-07-2025

    Purpose This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I and Phase II (Fast track) grant applications. The funding opportunity will utilize a UT1/UT2 cooperative agreement to support SBCs to propose the development of novel extracellular vesicle (EV)-based therapeutic platforms for ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-23-267: Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

    Release Date: 04-18-2023Open Date: 05-06-2023 Due Dates: Multiple Close Date: 06-07-2025

    Purpose This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support SBCs to propose the development of novel extracellular vesicle-based therape ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. RFA-MD-24-006: Innovations for Healthy Living- Improving Minority Health and Eliminating Health Disparities (R43/R44- Clinical Trial Optional)

    Release Date: 03-08-2024Open Date: 05-10-2024 Due Dates: Multiple Close Date: 12-10-2026

    Background Despite continued improvement in the health of the U.S. population with the introduction of medical and scientific advances, there continues to be an alarming disproportionate burden of illness among certain population groups. The mission of the NIMHD is to lead scientific research aimed at the development of innovative diagnostics, treatments, and prevention strategies to improve mino ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PAR-23-213: Interactive Digital Media (IDM) Biomedical Science Resources for Pre-College Students and Teachers (SBIR) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 06-15-2023Open Date: 08-05-2023 Due Dates: Multiple Close Date: 09-06-2025

    Interactive Digital Media (IDM) refers to products and services on digital computer-based systems which respond to the user’s actions by presenting content in the form of text, images, animations, audios, videos, and video games. These products and services have been widely used in science, technology, engineering, and mathematics (STEM) education to enrich student's learning experience both ins ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-22-103: Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (UT1/UT2 Clinical Trial Optional)

    Release Date: 01-21-2022Open Date: 02-28-2022 Due Dates: Multiple Close Date: 12-05-2024

    Background Currently, there are only three medications (four formulations) approved by the FDA for the treatment of alcohol use disorder (AUD). The need for additional medications to treat those affected by AUD is urgently needed.In addition,alcohol misuseaffects virtually all tissues and is linked with dysfunction and failure of many organs and systems including the liver, heart, pancreas, lung, ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-22-102: Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (U43/U44 Clinical Trial Optional)

    Release Date: 01-21-2022Open Date: 02-28-2022 Due Dates: Multiple Close Date: 12-05-2024

    Background Currently, there are only three medications (four formulations) approved by the FDA for the treatment of alcohol use disorder (AUD). The need for additional medications to treat those affected by AUD is urgently needed.In addition,alcohol misuseaffects virtually all tissues and is linked with dysfunction and failure of many organs and systems including the liver, heart, pancreas, lung, ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. A244-036: Laminated Metallic Armor

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Infrastructure & Advanced Manufacturing; Sustainment & Logistics; Advanced Materials; OBJECTIVE: This topic is seeking innovative, readily scalable manufacturing technologies to cost-effectively produce laminated/graded metallic armor plate and high strength structural components that are readily integrable. DESCRIPTION: The Army is seeking ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
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