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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. RFA-DA-23-021: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44- Clinical Trial Optional)

    Release Date: 03-28-2022Open Date: 07-15-2022 Due Dates: Multiple Close Date: 02-14-2025

    According to the Centers for Disease Control and Prevention (CDC), more than 100,000 deaths from overdose were reported from April 2020 to April 2021 alone. Data shows an increase in overdoses due to natural and semi-synthetic opioids, synthetic opioids, predominantly fentanyl, and psychostimulants, such as methamphetamine or cocaine. In fact, in the year ending in April 2021, fentanyl was the lea ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. 1: Address the needs of individuals with disabilities

    Release Date: 04-05-2022Open Date: 04-05-2022Due Date: 06-06-2022Close Date: 06-06-2022

    The purpose of the Federal SBIR program is to stimulate technological innovation in the private sector, strengthen the role of small business in meeting Federal research or research and development (R/R&D) needs, and improve the return on investment from Federally-funded research for economic and social benefits to the nation. The specific purpose of NIDILRR's SBIR program is to improve the lives ...

    SBIRPhase IIDepartment of Health and Human ServicesAdministration for Community Living
  3. RFA-CA-22-025: SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

    Release Date: 04-05-2022Open Date: 07-05-2022Due Date: 08-05-2022Close Date: 08-05-2022

    Purpose The Small Business Innovation Research (SBIR) Program is an important mechanism by which the National Institutes of Health (NIH) and other Federal agencies help bring innovative solutions to public health challenges. A major objective of the Federal SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of medi ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. SF22B-T001: Co Orbital Threat Prediction and Assessment

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Network Command, Control and Communications; Artificial Intelligence/Machine Learning TECHNOLOGY AREA(S): Space Platform; Battlespace The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export ...

    STTRPhase IDepartment of DefenseAir Force
  5. SF22B-T002: Improved Integrated Circuit based Electricity to Radio Frequency Conversion Efficiency Development for Space based Applications

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Microelectronics; Directed Energy; 5G TECHNOLOGY AREA(S): Electronics; Space Platform; Materials; Information Systems; Air Platform; Battlespace The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, inclu ...

    STTRPhase IDepartment of DefenseAir Force
  6. SF22B-T003: Variable Emissivity Thermal Control Capability Development for Space based Applications

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Quantum Sciences TECHNOLOGY AREA(S): Space Platform; Materials The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation ( ...

    STTRPhase IDepartment of DefenseAir Force
  7. AF22B-T004: Collaboration of Humans and Autonomy Research Teaming Testbed (CHART2)

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Network Command, Control and Communications; Autonomy TECHNOLOGY AREA(S): Ground Sea; Space Platform; Information Systems; Air Platform OBJECTIVE: The objective of this topic is to develop a mid-fidelity stand-alone testbed for critical research on human-autonomy teaming concepts that uses command and control (C2) tasks relevant to Joint All Domain Comman ...

    STTRPhase IDepartment of DefenseAir Force
  8. AF22B-T005: Complex Emitter Behavioral Analysis Using Machine Learning

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Autonomy; Artificial Intelligence/Machine Learning TECHNOLOGY AREA(S): Sensors The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administrat ...

    STTRPhase IDepartment of DefenseAir Force
  9. SF22B-T006: Self-Regulating Heaters for Satellites

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Autonomy TECHNOLOGY AREA(S): Space Platform The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts ...

    STTRPhase IDepartment of DefenseAir Force
  10. OSD22B-001: Scalable Production of Engineered Designer Proteins Containing Multiple Distinct Non-canonical Amino Acids

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Biotechnology TECHNOLOGY AREA(S): Materials OBJECTIVE: Develop cellular or cell-free synthetic processes from genomically recoded organisms to achieve robust, reliable and cost-effective production of engineered proteins containing multiple distinct non-canonical amino acids that are scalable to manufacturing-relevant levels. DESCRIPTION: Biological s ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
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