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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. OSD22B-001: Scalable Production of Engineered Designer Proteins Containing Multiple Distinct Non-canonical Amino Acids

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Biotechnology TECHNOLOGY AREA(S): Materials OBJECTIVE: Develop cellular or cell-free synthetic processes from genomically recoded organisms to achieve robust, reliable and cost-effective production of engineered proteins containing multiple distinct non-canonical amino acids that are scalable to manufacturing-relevant levels. DESCRIPTION: Biological s ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  2. OSD22B-002: Intelligent Multi-Laser System for Metal Additive Manufacturing

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Artificial Intelligence/ Machine Learning TECHNOLOGY AREA(S): Materials; Information Systems OBJECTIVE: To significantly accelerate the laser metal powder bed additive manufacturing (LPBAM) process and improve the microstructural quality of LPBAM parts by developing a scalable, intelligent multi-laser based system. In this AM system, some of the lasers q ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  3. OSD22B-003: Monolithic CMOS Integration of SiGeSn High Performance Optoelectronic Devices

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Microelectronics; Network Command, Control and Communications; General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Sensors; Electronics; Chem Bio Defense; Space Platforms; Materials; Information Systems OBJECTIVE: Develop a SiGeSn monolithic integration technology with CMOS for optoelectronic devices operating in the wavelength range between 2.0 an ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  4. OSD22B-004: Ultra-Pure Atomic Wafer Fusion for Ultra-Wide Bandgap, Ultra-High Power, High Thermal Conductivity Power Switches

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Microelectronics; Network Command, Control and Communications; General Warfighting Requirements TECHNOLOGY AREA(S): Ground Sea; Electronics; Materials OBJECTIVE: Develop a high purity, ultra-high vacuum surface activated bonded wafer fusion (UHV-SAB) tool for heterogeneous integration of dissimilar materials for electronic materials integration and therma ...

    STTRPhase IDepartment of DefenseOffice of the Secretary of Defense
  5. OSD222-003: Personnel Accountability Data Management to Improve Accountability and Readiness

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: General Warfighting Requirements (GWR) TECHNOLOGY AREA(S): Information Systems OBJECTIVE: Provide innovations for restructuring the current state of the Personnel Accountability Programs. DESCRIPTION: A full scope portfolio assessment will be necessary to review capabilities, technical information, data feeds, and gaps to provide recommendations for t ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  6. OSD222-D02: Advanced Integrated CMOS Terahertz (THz) Focal Plane Arrays (FPA)

    Release Date: 04-20-2022Open Date: 05-18-2022Due Date: 06-15-2022Close Date: 06-15-2022

    OUSD (R&E) MODERNIZATION PRIORITY: Microelectronics, AI/ML TECHNOLOGY AREA(S): Information Systems, Modeling and Simulation Technology OBJECTIVE: Develop advanced THz-FPA that offer large pixel count, high dynamic range, and high speed over a broad THz frequency range. DESCRIPTION: Electromagnetic waves in the THz spectral band (roughly covering the 0.1 – 3 THz frequency range) offer ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice of the Secretary of Defense
  7. RFA-ES-22-004: SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)

    Release Date: 04-26-2022Open Date: 06-20-2022Due Date: 07-20-2022Close Date: 07-21-2022

    This SBIR Funding Opportunity Announcement (FOA) focuses on the development of e-Learning health and safety training products from a variety of delivery methods to assist both students and instructors in the training and education process. Note that all products must be directly related to the health and safety training of workers exposed to hazardous materials (HAZMAT). Workers that may be expose ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. RFA-CA-22-025: SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

    Release Date: 04-05-2022Open Date: 07-05-2022Due Date: 08-05-2022Close Date: 08-05-2022

    Purpose The Small Business Innovation Research (SBIR) Program is an important mechanism by which the National Institutes of Health (NIH) and other Federal agencies help bring innovative solutions to public health challenges. A major objective of the Federal SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of medi ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. RFA-DA-23-021: Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R43/R44- Clinical Trial Optional)

    Release Date: 03-28-2022Open Date: 07-15-2022 Due Dates: Multiple Close Date: 02-14-2025

    According to the Centers for Disease Control and Prevention (CDC), more than 100,000 deaths from overdose were reported from April 2020 to April 2021 alone. Data shows an increase in overdoses due to natural and semi-synthetic opioids, synthetic opioids, predominantly fentanyl, and psychostimulants, such as methamphetamine or cocaine. In fact, in the year ending in April 2021, fentanyl was the lea ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. RFA-CA-22-017: Small Business Transition Grant For Early Career Scientists (R42 Clinical Trial Not Allowed)

    Release Date: 03-21-2022Open Date: 07-22-2022Due Date: 08-22-2022Close Date: 08-23-2022

    Purpose Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI), National Institute of Biomedical Imaging and Bioengineering (NIBIB), and National Institute on Drug Abuse (NIDA) intend to support early-career academic scientists interested in transitioning to entrepreneurship while also supporting the transfer of technology from academic laboratories into small bu ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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