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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. CT1: Biochemicals

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    CT1 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  2. M2: Bio-Inspired Manufacturing

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    M2 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  3. BT2: Bio-Inspired Technologies

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    BT2 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  4. BT3: Bioinstruments

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    BT3 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  5. BT: Biological Technologies (BT)

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    The Biological Technologies topic covers a wide range of technology areas to advance engineering and science innovation across the biological spectrum. Biological technologies have disrupted decades-old chemical, agricultural, and medical products and services, producing a new bioeconomy. Potential breakthroughs in this space are on course to make major socioeconomic contributions to the economy b ...

    SBIRPhase INational Science Foundation
  6. RFA-HD-22-018: Biomarker Research to Support Fertility Regulation Development by Small Business (R43 Clinical Trial Optional)

    Release Date: 04-15-2021Open Date: 06-29-2021Due Date: 07-29-2021Close Date: 07-30-2021

    Purpose The purpose of this Funding Opportunity Announcement (FOA) is to invite SBIR applications to support and facilitate the development of new and/or improved clinical biomarkers and companion biomarker diagnostics (e.g., point of care and/or direct-to-consumer tests, DTC) to support the clinical development of non-hormonal contraceptive product(s) for men and women. Background Nearly half ...

    SBIRPhase IDepartment of Health and Human ServicesNational Institutes of Health
  7. BM: Biomedical Technologies (BM)

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    The Biomedical Technologies topic aims to support the early-stage development of novel products, processes, or services that will enable the delivery of high-quality, economically-efficient healthcare. Subtopics are not aimed at supporting or conducting clinical trials, clinical efficacy or safety studies, the development pre-clinical or clinical-stage drug candidates or medical devices, or work ...

    SBIRPhase INational Science Foundation
  8. BT4: Biosensors

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    BT4 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  9. DL2: Blockchain, DAGs, and Next-Gen Protocols

    Release Date: 02-12-2021Open Date: 02-12-2021 Due Dates: Multiple Close Date: 12-02-2021

    DL2 NSF SBIR Phase I (2021) National Science Foundation ...

    SBIRPhase INational Science Foundation
  10. PAR-21-233: Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 04-23-2021Open Date: 07-10-2021 Due Dates: Multiple Close Date: 04-06-2024

    A. Overview Recent advances in biology offer unprecedented opportunities to discover new treatments for nervous system disorders. Biotherapeutic development, however, has inherent complexities with regards to characterization, manufacturing, delivery, and administration. Many academic laboratories and small business enterprises don’t have the full scope of expertise and resources available; thi ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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