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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. HHS-2024-ACL-NIDILRR-BISB-0070: Small Business Innovation Research Program (SBIR) Phase II

    Release Date: 01-05-2024Open Date: 01-05-2024Due Date: 03-05-2024Close Date: 03-05-2024

    The purpose of the Federal SBIR program is to stimulate technological innovation in the private sector, strengthen the role of small business in meeting Federal research or research and development (R/R&D) needs, and improve the return on investment from Federally-funded research for economic and social benefits to the nation. The specific purpose of NIDILRR's SBIR program is to improve the lives ...

    SBIRPhase IIDepartment of Health and Human ServicesAdministration for Community Living
  2. PAR-24-044: NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required)

    Release Date: 11-27-2023Open Date: 12-05-2023 Due Dates: Multiple Close Date: 09-06-2026

    NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treatment of n ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-23-311: NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required)

    Release Date: 11-27-2023Open Date: 12-05-2023 Due Dates: Multiple Close Date: 09-06-2026

    NINDS is committed to advancing diagnostics and treatments for people burdened by neurological diseases, and the NINDS Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies and therapeutics for the diagnosis and treatment of n ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-TR-24-001: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 12-01-2023Open Date: 12-04-2023 Due Dates: Multiple Close Date: 03-16-2024

    While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underlie multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molecular etiologi ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-24-066: NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required)

    Release Date: 11-30-2023Open Date: 12-01-2023 Due Dates: Multiple Close Date: 01-08-2027

    This Notice of Funding Opportunity (NOFO) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials related to the research mission of the NEI. This program provides support for milestone-driven, commercialization-oriented clinical trials and will involve participation of NEI program ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. 8.1: Forests and Related Resources

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Forests and Related Resources topic area aims to address the health, diversity, and productivity of the Nation’s forests to meet the needs of present and future generations through the development of environmentally sound approaches to increase productivity of forest lands, improve sustainability and develop value-added materials derived from forest resources.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  7. 8.2: Plant Production and Protection – Biology

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The objective of this topic area is to develop novel ways of enhancing crop production and protection against abiotic and/or biotic stresses through the use of novel diagnostic technologies, plant improvement approaches, and tools or management practices that ensure healthy pollinators.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  8. 8.3: Animal Production and Protection

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Animal Production and Protection topic area aims to develop innovative, marketable technologies that will provide significant benefit to the production and protection of agricultural animals.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  9. 8.4: Conservation of Natural Resources

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Conservation of Natural Resources topic area aims to develop innovative technologies that are developed with the purpose to conserve, monitor, improve and/or protect the quality and/or quantity of natural resources while sustaining optimal farm and forest productivity and profitability. We encourage new technologies and innovations that will help improve soil health, reduce soil erosion, impro ...

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  10. 8.5: Food Science and Nutrition

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Food Science and Nutrition topic area aims to fund projects that support research focusing on developing new and improved processes, technologies, or services that address emerging food safety, food processing, and nutrition issues.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
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