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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. N232-094: Blockchain-based, Highly Secure, Decentralized, and Immutable (DSI) Network System Protocol for Multifunction Advanced Data Link (MADL)

    Release Date: 04-19-2023Open Date: 05-17-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Computing and Software;FutureG;Integrated Network Systems-of-Systems OBJECTIVE: Design and develop a secure blockchain-based system for manned aerial platform air-to-air and air-to-ground secure communication. DESCRIPTION: The manned aerial platform can share information two ways in combat across radio datalinks and other innovations to pass targe ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
  2. DL2: Blockchain, DAGs, and Next-Gen Protocols

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    NA

    SBIR/STTRPhase INational Science Foundation
  3. PAR-21-282: Blueprint Medtech: Small Business Translator (U44- Clinical Trial Optional)

    Release Date: 08-20-2021Open Date: 09-20-2021 Due Dates: Multiple Close Date: 06-21-2024

    Blueprint MedTech The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/). Innovators developing groundbreaking medical ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PAR-21-233: Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 04-23-2021Open Date: 07-10-2021 Due Dates: Multiple Close Date: 04-06-2024

    A. Overview Recent advances in biology offer unprecedented opportunities to discover new treatments for nervous system disorders. Biotherapeutic development, however, has inherent complexities with regards to characterization, manufacturing, delivery, and administration. Many academic laboratories and small business enterprises don’t have the full scope of expertise and resources available; thi ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-21-162: Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 03-29-2021Open Date: 07-10-2021 Due Dates: Multiple Close Date: 04-06-2024

    A. Overview Recent advances in biology offer unprecedented opportunities to discover new treatments for nervous system disorders. Biotherapeutic development, however, has inherent complexities with regards to characterization, manufacturing, delivery, and administration. Many academic laboratories and small business enterprises don’t have the full scope of expertise and resources available; thi ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. RFA-TR-22-031: Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (UT1, UT2 Clinical Trail Not Allowed)

    Release Date: 09-19-2022Open Date: 10-20-2022 Due Dates: Multiple Close Date: 08-22-2023

    This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR)Phase I and Phase II (no Direct to Phase II allowed) grant applications. The funding opportunity will utilize a UT1/UT2 cooperative agreement to support small business concerns (SBCs) to propose applications for the qualification of neuromuscu ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. RFA-TR-22-032: Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44- Clinical Trail Not Allowed)

    Release Date: 09-19-2022Open Date: 10-21-2022 Due Dates: Multiple Close Date: 08-22-2023

    Section I. Funding Opportunity Description This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR)Phase I and Phase II (Fast track and Direct to phase II) grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support small business concerns (SBCs) to propose a ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. A23B-T008: Bright Blue Semiconductor Laser Arrays for Military Applications

    Release Date: 04-19-2023Open Date: 05-18-2023Due Date: 06-14-2023Close Date: 06-14-2023

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Network System of Systems, Directed Energy OBJECTIVE: Develop compact chip-scale blue laser systems with high beam quality useful for machining and propagation. Advances based upon the coherent beam combining of diode lasers of high brightness are sought. DESCRIPTION: Laser systems in the infrared have a long history of development for both DoD ...

    STTRPhase IDepartment of DefenseArmy
  9. CT2: Catalysts, Advanced Chemicals and Materials

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    NA

    SBIR/STTRPhase INational Science Foundation
  10. BT4: Cell and Tissue Engineering

    Release Date: 11-22-2022Open Date: 11-22-2022 Due Dates: Multiple Close Date: 11-01-2023

    NA

    SBIR/STTRPhase INational Science Foundation
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