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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. A244-030: Miniaturization of Hyperspectral Sensors for UAS Applications

    Release Date: 10-03-2023Open Date: 05-13-2024Due Date: 03-31-2025Close Date: 07-01-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Integrated Sensing and Cyber; Microelectronics OBJECTIVE: Further develop existing sensor or prototype to meet the necessary Size, Weight and Power (SWaP) requirements for integration into various ongoing modernization programs. This topic seeks to develop a direct-to-phase-two, internally calibrated, compact, passive, day/night capable hyperspectral (hu ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  2. RFA-TR-23-017: Miniaturization and Automation of Tissue Chip Systems (MATChS) (U43/U44 Clinical Trial Not Allowed)

    Release Date: 11-22-2023Open Date: 01-22-2024 Due Dates: Multiple Close Date: 02-24-2026

    This Notice of Funding Opportunity (NOFO) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I, Phase II, Fast-Track and Direct to Phase II grant applications. The funding opportunity will utilize a U43/U44 cooperative agreement to support small business concerns (SBCs) to propose applications to create bench top, portable, autom ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-TR-23-018: Miniaturization and Automation of Tissue Chip Systems (MATChS) (UT1/UT2- Clinical Trial Not Allowed)

    Release Date: 11-22-2023Open Date: 01-22-2024 Due Dates: Multiple Close Date: 02-24-2026

    This Notice of Funding Opportunity (NOFO) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, Phase II, and Fast-Track grant applications. The funding opportunity will utilize a UT1/UT2 cooperative agreement to support small business concerns (SBCs) to propose applications to create bench top, portable, automated, self-containe ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. 3: Microscope for time-resolved emission microscopy with superconducting-nanowire single-photon detectors

    Release Date: 04-16-2024Open Date: 04-16-2024Due Date: 06-14-2024Close Date: 06-14-2024

    Closed Topic Title

    SBIRPhase I/Phase IIDepartment of CommerceNational Institute of Standards and Technology
  5. 7: Metrology to Enhance Security and Provenance of Microelectronic-based Components and Product

    Release Date: 04-16-2024Open Date: 04-16-2024Due Date: 06-14-2024Close Date: 06-14-2024

    Open Topic Title

    SBIRPhase I/Phase IIDepartment of CommerceNational Institute of Standards and Technology
  6. 1: Metrology for Materials Purity, Properties, and Provenance

    Release Date: 04-16-2024Open Date: 04-16-2024Due Date: 06-14-2024Close Date: 06-14-2024

    Open Topic Title

    SBIRPhase I/Phase IIDepartment of CommerceNational Institute of Standards and Technology
  7. A244-048: Lightweight AI-enabled image processing for Soldier-borne thermal imagers

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy, Microelectronics, Integrated Sensing and Cyber, Advanced Computing and Software The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  8. PAR-23-032: Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)

    Release Date: 10-27-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-06-2025

    Purpose This Funding Opportunity Announcement (FOA) encourages the translation of technology and therapeutic innovations from academic and other non-profit research sectors to the marketplace to advance the development of diagnostic and prevention tools or treatments for musculoskeletal, rheumatic, or skin diseases. Small Business Concerns (SBCs) are encouraged to apply for this Small Business In ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. A244-036: Laminated Metallic Armor

    Release Date: 10-03-2023Open Date: 06-10-2024Due Date: 03-31-2025Close Date: 07-29-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Advanced Infrastructure & Advanced Manufacturing; Sustainment & Logistics; Advanced Materials; OBJECTIVE: This topic is seeking innovative, readily scalable manufacturing technologies to cost-effectively produce laminated/graded metallic armor plate and high strength structural components that are readily integrable. DESCRIPTION: The Army is seeking ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  10. PAR-22-102: Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (U43/U44 Clinical Trial Optional)

    Release Date: 01-21-2022Open Date: 02-28-2022 Due Dates: Multiple Close Date: 12-05-2024

    Background Currently, there are only three medications (four formulations) approved by the FDA for the treatment of alcohol use disorder (AUD). The need for additional medications to treat those affected by AUD is urgently needed.In addition,alcohol misuseaffects virtually all tissues and is linked with dysfunction and failure of many organs and systems including the liver, heart, pancreas, lung, ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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