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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. CDC/NCHHSTP 052: Electronic Health Record Algorithm to Identify Persons with HIV Not in Care

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I: up to $243,500 for up to 6 months; Phase II of up to $1,000,000 and a Phase II duration of up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Electr ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesCenters for Disease Control and Prevention
  2. CDC/NCHHSTP 053 : Simultaneous Detection of Molecular and Serological Markers via Next-Generation Sequencing

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I: up to $243,500 for up to 6 months; Phase II of up to $1,000,000 and a Phase II duration of up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Simult ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesCenters for Disease Control and Prevention
  3. CDC/NCIRD 035: Nanoparticle-based Multi-Antigen Influenza Vaccine that Induces both Antibody and Cell-Mediated Immune Responses

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I: up to $243,500 for up to 6 months; Phase II of up to $1,000,000 and a Phase II duration of up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Influe ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-AG-22-007: NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional)

    Release Date: 06-10-2021Open Date: 09-26-2021Due Date: 10-26-2021Close Date: 10-27-2021

    The number of available tenure-track faculty positions has not kept pace with the growing number of Ph.D. graduates in recent years. This imbalance has created a very competitive job environment, making it increasingly difficult for Ph.D. graduates to transition to academic appointments. Doctoral and post-doctoral training programs have heavily revolved around developing skill sets that are direct ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. CBD213-001: Surface-Enhanced Raman Scattering Substrate Development

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: To develop a metallic surface-enhanced Raman scattering (SERS) substrate to be utilized for augmentation of current/future Raman spectroscopic portable instrumentation for the detection of trace and residual chemical materials. The substrates should consist of nanostructured metals, preferably gold or silver, on a porous or non-porous material backing (such as filter paper, silicon, ga ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice for Chemical and Biological Defense
  6. CBD213-002: Millimeter Wave Imaging with Metamaterials

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: To develop a low-cost millimeter wave imager based on pyroelectric metamaterial absorbers. The goal is to develop an advanced composite detector fashioned from metamaterials that can be assembled into compact arrays for low cost hyperspectral and high sensitivity W-band imaging applications. DESCRIPTION: Millimeter wave imaging has been shown to be a useful tool in the detection of p ...

    SBIRPhase I/Phase IIDepartment of DefenseOffice for Chemical and Biological Defense
  7. NGA-213-1: Land Use from Nontraditional Analytics

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: This announcement seeks proposals to develop a flexible and adaptable artificial intelligence (AI) system capable of classifying fine-grained subcategories of urban land use via the fusion of imagery, remote sensing, and non-imagery geospatial data layers. DESCRIPTION: For decades, geographers have used land use maps to quantify and depict spatial heterogeneities in land use and land c ...

    SBIRPhase I/Phase IIDepartment of DefenseNational Geospatial-Intelligence Agency
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