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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. CDC/NCHHSTP 052: Electronic Health Record Algorithm to Identify Persons with HIV Not in Care

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I: up to $243,500 for up to 6 months; Phase II of up to $1,000,000 and a Phase II duration of up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Electr ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesCenters for Disease Control and Prevention
  2. CDC/NCHHSTP 053 : Simultaneous Detection of Molecular and Serological Markers via Next-Generation Sequencing

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I: up to $243,500 for up to 6 months; Phase II of up to $1,000,000 and a Phase II duration of up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Simult ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesCenters for Disease Control and Prevention
  3. CDC/NCIRD 035: Nanoparticle-based Multi-Antigen Influenza Vaccine that Induces both Antibody and Cell-Mediated Immune Responses

    Release Date: 07-12-2021Open Date: 07-12-2021Due Date: 10-28-2021Close Date: 10-28-2021

    Phase I SBIR proposals will be accepted. Fast-Track proposals will not be accepted. Phase I clinical trials will not be accepted. Number of anticipated awards: 1 Budget (total costs): Phase I: up to $243,500 for up to 6 months; Phase II of up to $1,000,000 and a Phase II duration of up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Background Influe ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-ES-21-008: Innovative Approaches for Improving Environmental Health Literacy (R43/R44 Clinical Trial Not Allowed)

    Release Date: 08-12-2021Open Date: 10-10-2021Due Date: 11-10-2021Close Date: 11-11-2021

    Background The National Institute of Environmental Health Sciences (NIEHS) continues to support innovative and diverse partnerships to bring environmental health science concepts to various audiences with the goal of improving their environmental health literacy (https://www.niehs.nih.gov/about/strategicplan/2018-2023_theme2/index.cfm). At the most fundamental level, environmental health literacy ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-21-282: Blueprint Medtech: Small Business Translator (U44- Clinical Trial Optional)

    Release Date: 08-20-2021Open Date: 09-20-2021 Due Dates: Multiple Close Date: 06-21-2024

    Blueprint MedTech The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/). Innovators developing groundbreaking medical ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. A21-102: Dynamic Characterization of Critical Material Properties

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  7. A21-101: Modern, Safe, and Affordable Processes for Production of Energetic Polymers (BAMO-AMMO)

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  8. A21-103: Easily Processed High Tg polymers

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  9. A21-104: High-pressure pumps with minimal mechanical interfaces for low lubricity fuels

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    OBJECTIVE: Design, develop, and demonstrate innovative methods of pressurizing low-viscosity and low-lubricity fuels for delivery to high-pressure fuel injection systems that avoid or reduce sliding mechanical interfaces vulnerable to inadequate lubrication. DESCRIPTION: High pressure common rail (HPCR) injection systems are used in internal combustion (IC) engines for several Army aviation and g ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
  10. A21-105: Unmanned aerial system for organic squad-level situational awareness

    Release Date: 08-25-2021Open Date: 09-21-2021Due Date: 10-21-2021Close Date: 10-21-2021

    The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual use items. Offerors must disclose any proposed use of fore ...

    SBIRPhase I/Phase IIDepartment of DefenseArmy
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