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Extreme Events and Cascading Hazards --- Topic 9.1 Societal Challenge Communities across the U.S., particularly underserved communities, face enduring, compounding risks from extreme, high-impact weather, water, and climate events, which have become more severe and more frequent in recent decades. Overview In the context of a warming, changing climate, extreme weather, water, and climate events ...

Coastal Resilience --- Topic 9.2 Societal Challenge U.S. coastal communities, economies, and ecosystems, as well as the natural and built infrastructure on which they depend, are increasingly impacted by accelerating changes at the coast. Creating resilience to these changes requires risk-informed decision making and adaptation via enhanced emergency response, coastal data collection, and predic ...

The Changing Ocean --- Topic 9.3 Societal Challenge Ocean warming, decreasing sea ice, changing currents, rising seas, ocean acidification, and deoxygenation are affecting the nation’s valuable living marine resources and many ocean-dependent businesses and communities. These changes impact the nation’s security through many sectors from marine navigation, transportation, and energy, to fishe ...

Water Availability, Quality, and Risk --- Topic 9.4 Societal Challenge The U.S. is facing emerging threats to our economic and national security and ecosystem and habitat health from competing demands for our increasingly limited and stressed water supply and other water risks nationwide, in the context of aging water infrastructure, degrading water quality, population growth, and climate change. ...

Effects of Space Weather --- Topic 9.5 Societal Challenge The effects of space weather pose significant and increasing societal, economic, national security, and health risks to the United States and nations worldwide. These include risks to the electric power grid; aviation operations; positioning, navigation, and timing (PNT) services; satellites and communications; human space exploration; and ...

Monitoring and Modeling for Climate Change Mitigation --- Topic 9.6 Societal Challenge Worldwide, there is now widespread recognition of the impact of greenhouse gas emissions on the climate system, leading to dangerous, accelerated warming. Within the U.S. and internationally, there is a growing demand for information about current and future greenhouse gas emissions, their impact on the state o ...

The objective of this Funding Opportunity Announcement (FOA) is to support the development of new and innovative long-acting systemic and non-systemic multipurpose prevention technologies (MPT). It supports development of MPTs that prevent HIV infection and pregnancy (hormonal and non-hormonal methods) in adolescent and young women. Applications for MPT development may involve pharmacokinetic (PK) ...

(Fast-Track and Direct to Phase 2 proposals will not be accepted. Phase II information is provided only for informational purposes to assist Phase I offerors with their long-term strategic planning.) Number of anticipated awards: 2 to 3 Budget (total costs, per award): Phase I: $325,000 for 9 months; Phase II: $2,000,000 for 2 years It is strongly suggested that proposals adhere to the above budge ...

Fast-Track proposals will be accepted. Direct-to-Phase II proposals will NOT be accepted. Number of anticipated awards: 3-5 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATION LISTED ABOVE MAY NOT BE FUNDED. Page 79 Summary Among men, prostate cancer is the second leading caus ...

Fast-Track proposals will be accepted. Direct-to-Phase II proposals will be accepted. Only Direct-to-Phase II and Fast-Track proposals will be accepted. Phase I proposals will NOT be accepted. Number of anticipated awards: 3-5 Budget (total costs, per award): Phase I: up to $400,000 for up to 12 months Phase II: up to $2,000,000 for up to 2 years PROPOSALS THAT EXCEED THE BUDGET OR PROJECT DURATIO ...