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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-17-201 : Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44)

    Release Date: 03-09-2017Open Date: 07-09-2017 Due Dates: Multiple Close Date: 05-07-2020

    A. Overview Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food an ...

    SBIR Department of Health and Human Services
  2. PAR-18-541 : Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

    Release Date: 12-21-2017Open Date: 01-07-2018 Due Dates: Multiple Close Date: 05-07-2020

    A. Overview Recent advances in neuroscience offer unprecedented opportunities to discover new treatments for nervous system disorders. However, before a new chemical entity can be tested in a clinical setting, it must undergo a process of chemical optimization to improve potency, selectivity, and drug-like properties, followed by pre-clinical safety testing to meet the standards set by the Food ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  3. RFA-HL-19-016: Technologies for Healthy Independent Living for Heart, Lung, Blood and Sleep Disorders (R43- Clinical Trial Not Allowed)

    Release Date: 03-15-2018Open Date: 05-11-2018 Due Dates: Multiple Close Date: 06-10-2020

    The average age of the U.S. population is climbing because people living longer. Chronic health conditions related to heart, lung, blood, and sleep (HLBS) disorders are becoming more prevalent as part of natural aging. Technological advances and the needs of older adults create an opportunity for the design and development of home digital health technologies that could enable functional independen ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  4. RFA-HL-19-018 : NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

    Release Date: 05-16-2018Open Date: 06-27-2018 Due Dates: Multiple Close Date: 07-09-2020

    Purpose The Small Business Innovation Research (SBIR) Program is an important National Institutes of Health (NIH) funding mechanism used to develop innovative solutions that address public health challenges. A major objective of the SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of biomedical products is ofte ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  5. RFA-HL-19-017 : NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

    Release Date: 05-16-2018Open Date: 06-27-2018 Due Dates: Multiple Close Date: 07-09-2020

    Purpose The Small Business Innovation Research (SBIR) Program is an important funding mechanism that the National Institutes of Health (NIH) uses to develop innovative solutions that address public health challenges. A major objective of the SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of biomedical product ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  6. PAR-17-457 : CREATE Bio Optimization Track for Biologics (SBIR-U44)

    Release Date: 08-14-2017Open Date: 01-13-2018 Due Dates: Multiple Close Date: 09-07-2020

    A. Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biologics (CREATE Bio) program is dedicated to biotechnology product- and biologics-based th ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  7. PAR-18-543 : CREATE Bio Development Track: Nonclinical and Early-Phase Clinical Development for Biologics (U44 Clinical Trial Optional)

    Release Date: 12-20-2017Open Date: 01-20-2018 Due Dates: Multiple Close Date: 09-07-2020

    A.  Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biologics (CREATE Bio) program is dedicated to biotechnology products and biologic ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  8. PAR-18-549 : Analytical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional)

    Release Date: 12-22-2017Open Date: 02-14-2018 Due Dates: Multiple Close Date: 09-07-2020

    Purpose The overarching purpose of this Funding Opportunity Announcement (FOA) is to fill critical scientific gaps needed to advance strong candidate biomarkers of neurological disease from discovery to clinical use. Specifically, the focus of this FOA is on the validation of analytical methods for biomarker measurements, including evaluation of the assay, its performance characteristics, and t ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  9. PAR-18-548 : Clinical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional)

    Release Date: 12-22-2017Open Date: 02-14-2018 Due Dates: Multiple Close Date: 09-07-2020

    Purpose The overarching purpose of this Funding Opportunity Announcement (FOA) is to fill critical scientific gaps needed to advance strong candidate biomarkers from discovery to clinical use. Specifically, the focus of this FOA is to support the clinical validation of candidate biomarkers of neurological disease using retrospective and/or prospective methods. Research supported by this FOA sho ...

    SBIR Department of Health and Human ServicesNational Institutes of Health
  10. PAR-18-543 : CREATE Bio Development Track: Nonclinical and Early-Phase Clinical Development for Biologics (U44 Clinical Trial Optional)

    Release Date: 12-20-2017Open Date: 01-20-2018 Due Dates: Multiple Close Date: 09-07-2020

    A.  Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biologics (CREATE Bio) program is dedicated to biotechnology products and biologic ...

    SBIR Department of Health and Human ServicesNational Institutes of Health

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