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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-24-133: Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Not Allowed)

    Release Date: 04-26-2024Open Date: 08-05-2024 Due Dates: Multiple Close Date: 04-06-2027

    The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, also known as America's Seed Fund, are one of the largest sources of early-stage capital for technology commercialization in the United States. These programs enable US-owned and operated small businesses to conduct research and development that has a strong potential for commercialization. The Na ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  2. PAR-24-131: Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed)

    Release Date: 04-26-2024Open Date: 08-05-2024 Due Dates: Multiple Close Date: 04-06-2027

    The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, also known as America's Seed Fund, are one of the largest sources of early-stage capital for technology commercialization in the United States. These programs enable US-owned and operated small businesses to conduct research and development that has a strong potential for commercialization. The Na ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAR-24-132: Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Required)

    Release Date: 04-26-2024Open Date: 08-05-2024 Due Dates: Multiple Close Date: 04-06-2027

    The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, also known as America's Seed Fund, are one of the largest sources of early-stage capital for technology commercialization in the United States. These programs enable US-owned and operated small businesses to conduct research and development that has a strong potential for commercialization. The Na ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. RFA-CA-24-022: SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

    Release Date: 04-23-2024Open Date: 07-21-2024Due Date: 08-21-2024Close Date: 08-22-2024

    The Small Business Innovation Research (SBIR) Program is an important mechanism by which the National Institutes of Health (NIH) and other Federal agencies help bring innovative solutions to public health challenges. A major objective of the Federal SBIR Program is to facilitate the commercialization of technologies developed by small business concerns (SBCs). Yet, the development of medical biote ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. RFA-CA-24-023: Small Business Transition Grant For Early Career Scientists (R41/R42 Clinical Trial Not Allowed)

    Release Date: 04-23-2024Open Date: 07-21-2024Due Date: 08-21-2024Close Date: 08-22-2024

    Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Human Genome Research Institute (NHGRI), and National Institute of Mental Health (NIMH) intend to support early-career academic scientists interested in transitioning to entrepreneurship while also supporting the transfer of technolog ...

    STTRPhase IDepartment of Health and Human ServicesNational Institutes of Health
  6. RFA-ES-24-003: SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)

    Release Date: 05-21-2024Open Date: 06-26-2024Due Date: 07-26-2024Close Date: 07-27-2024

    This SBIR NOFO focuses on the development of e-Learning health and safety training products from a variety of delivery methods to assist both students and instructors in the training and education process. Note that all products must be directly related to the health and safety training of workers exposed to hazardous materials (HAZMAT). Workers that may be exposed to these hazards include, but ar ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. RFA-DA-25-054: Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R43/R44 Clinical Trials Not Allowed)

    Release Date: 01-29-2024Open Date: 06-25-2024Due Date: 07-25-2024Close Date: 07-26-2024

    Background: Drug discovery and development is a high-cost, high-risk, and time-consuming endeavor where the failure rate of therapeutic candidates that enter clinical trials is 90%. Because of this, in recent years, artificial intelligence (AI), including machine learning ( ML) technologies, has been embraced to reduce clinical failure rates and to speed up drug discovery. AI/ML technologies are ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. RFA-DA-25-053: Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)

    Release Date: 01-29-2024Open Date: 06-25-2024Due Date: 07-25-2024Close Date: 07-26-2024

    Background: Drug discovery and development is a high-cost, high-risk, and time-consuming endeavor where the failure rate of therapeutic candidates that enter clinical trials is 90%. Because of this, in recent years, artificial intelligence (AI), including machine learning (ML) technologies, has been embraced to reduce clinical failure rates and to speed up drug discovery. AI/ML technologies are u ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. N244-P01: NAVAIR Open Topic for Advanced Robotic Automation for Fleet Readiness Center Industrial Processes

    Release Date: 10-03-2023Open Date: 06-12-2024Due Date: 03-31-2025Close Date: 09-03-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Trusted AI and Autonomy; Human-Machine Interfaces OBJECTIVE: The Naval Air Systems Command (NAVAIR) is seeking proposals from small businesses to advance the automation of industrial processes within Fleet Readiness Centers (FRCs). The aim is to enhance efficiency, quality, safety, pollution prevention, and productivity through the integration of advance ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
  10. N244-P02: NAVSEA Open Topic for Sustainment and Obsolescence

    Release Date: 10-03-2023Open Date: 06-12-2024Due Date: 03-31-2025Close Date: 09-03-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Sustainment OBJECTIVE: NAVSEA is seeking proposals for commercial technology to address Navy needs regarding sustainment and obsolescence. DESCRIPTION: NAVSEA requests proposals for existing technology demonstration platforms, prototypes, and commercial products that will reliably and safely get Navy assets back in the field as quickly as possible. F ...

    SBIRPhase I/Phase IIDepartment of DefenseNavy
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