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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. PAR-17-457 : CREATE Bio Optimization Track for Biologics (SBIR-U44)

    Release Date: 08-14-2017Open Date: 01-13-2018 Due Dates: Multiple Close Date: 09-07-2020

    A. Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biologics (CREATE Bio) program is dedicated to biotechnology product- and biologics-based th ...

    SBIRPhase IIDepartment of Health and Human Services
  2. PAR-18-303: Innovative Molecular Analysis Technology Development for Cancer Research and Clinical Care (R43/R44 Clinical Trial Not Allowed)

    Release Date: 10-03-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) proposing research for commercial development of novel cancer-relevant technologies. The proposed research projects are expected to focus on the development of highly-innovative technologies that improve molecular and/or cellular analysis of cancer ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. RFA-NS-18-012 : Translational Neural Devices (U44 Clinical Trial Required)

    Release Date: 11-08-2017Open Date: 01-21-2018 Due Dates: Multiple Close Date: 10-21-2020

    A. Overview This Funding Opportunity Announcement (FOA) seeks to encourage the translation of research discoveries into new treatments for disorders that affect the nervous system by supporting milestone-driven projects for the development, testing, and demonstration of therapeutic and diagnostic devices. This funding opportunity will utilize a Small Business Innovation Research (SBIR) U44 coope ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. PAR-18-512 : Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 12-20-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The Small Business Innovation Research (SBIR) program is a highly competitive program that encourages domestic small businesses to engage in Federal Research/Research and Development (R/R&D) that has the potential for commercialization. Through a competitive awards-based program, SBIR enables small businesses to explore their technological potential and provides the incentive to profit from its c ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  5. PAR-18-514 : Testing Lifespan/Healthspan-Extension Interventions in the Models of Alzheimer’s Disease (AD/ADRD) (R41/R42 Clinical Trial Not Allowed)

    Release Date: 12-20-2017Open Date: 03-06-2018 Due Dates: Multiple Close Date: 01-05-2021

    The Small Business Technology Transfer (STTR) program is a program that expands funding opportunities in the federal innovation research and development (R&D) arena. Central to the program is expansion of the public/private sector partnership to include the joint venture opportunities for small businesses and nonprofit research institutions. The unique feature of the STTR program is the requiremen ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. PAR-18-543 : CREATE Bio Development Track: Nonclinical and Early-Phase Clinical Development for Biologics (U44 Clinical Trial Optional)

    Release Date: 12-20-2017Open Date: 01-20-2018 Due Dates: Multiple Close Date: 09-07-2020

    A. Overview This Funding Opportunity Announcement (FOA) is part of a suite of complementary programs to encourage the translation of research discoveries into new treatments for disorders that fall under the NINDS mission. The NINDS Cooperative Research to Enable and Advance Translational Enterprises for Biologics (CREATE Bio) program is dedicated to biotechnology products and biologics-bas ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  7. PA-18-525 : Radiological/Nuclear Medical Countermeasure Product Development Program (SBIR) (R43/R44 Clinical Trial Not Allowed)

    Release Date: 12-19-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Purpose The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (SBIR) grant applications focused on specific product development activities for radiological/nuclear medical countermeasures leading to Investigational New Drug (IND) or Investigational Device Exemption (IDE) submission packages to the U.S. Food and Drug Administration (FDA). T ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  8. PAR-18-515 : BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR)(R41/R42 Clinical Trial Not Allowed)

    Release Date: 12-15-2017Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    Background The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is a Presidential project aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, shows how individual cells and complex ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  9. PAR-18-565 : Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44- Clinical Trial Optional)

    Release Date: 01-09-2018Open Date: 03-05-2018 Due Dates: Multiple Close Date: 01-05-2021

    The NIH and other research sponsors invest a significant amount of funds in the development of new technologies to study the brain and behavior, from basic and clinical perspectives, through a variety of mechanisms, including, from NIH, the R01, R21, R33, P01, P41, and P50 grants. This investment has produced a large number of technologies that include hardware (e.g., instruments, devices, etc.), ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. PAR-18-549 : Analytical Validation of a Candidate Biomarker for Neurological Disease (U44 Clinical Trial Optional)

    Release Date: 12-22-2017Open Date: 02-14-2018 Due Dates: Multiple Close Date: 09-07-2020

    Purpose The overarching purpose of this Funding Opportunity Announcement (FOA) is to fill critical scientific gaps needed to advance strong candidate biomarkers of neurological disease from discovery to clinical use. Specifically, the focus of this FOA is on the validation of analytical methods for biomarker measurements, including evaluation of the assay, its performance characteristics, and t ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
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