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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.


If no search results for your keyword(s) were found, you are encouraged to review Agency omnibus solicitations for additional funding opportunities. Omnibus solicitations are structured to be broad, extensive Programmatic issuances with research areas related to the petitioning Agency and are not limited to predetermined Topics/Subtopics. If upon reviewing you have additional questions, you may consider reaching out to the respective Agency for clarification regarding acceptable proposals (https://www.sbir.gov/agency-contacts).

  1. HR0011SB20244-01: Advanced Enabling High-Speed Technologies

    Release Date: 10-03-2023Open Date: 02-05-2024Due Date: 03-31-2025Close Date: 03-06-2024

    OUSD (R&E) CRITICAL TECHNOLOGY AREA(S): Hypersonics The technology within this topic is restricted under the International Traffic in Arms Regulation (ITAR), 22 CFR Parts 120-130, which controls the export and import of defense-related material and services, including export of sensitive technical data, or the Export Administration Regulation (EAR), 15 CFR Parts 730-774, which controls dual us ...

    SBIRPhase I/Phase IIDepartment of DefenseDefense Advanced Research Projects Agency
  2. PAS-22-197: Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)

    Release Date: 06-21-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-06-2025

    Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer’s Project Act and, the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and development proposals which, if pursued, have the potential to reduce the human burden and healthcare costs associated with AD/ADRD. As part of ...

    STTRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  3. PAS-22-196: Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

    Release Date: 06-21-2022Open Date: 12-05-2022 Due Dates: Multiple Close Date: 09-08-2025

    Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer’s Project Act and the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and development proposals which, if pursued, have the potential to reduce the human burden and healthcare costs associated with AD/ADRD. As part of t ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  4. 24-NH1: Algorithms for Computer Vision Inside and Outside the Vehicle

    Release Date: 02-08-2024Open Date: 02-08-2024Due Date: 03-07-2024Close Date: 03-07-2024

    24-NH1 FY24.1 DOT SBIR Solicitation Department of Transportation ...

    SBIRPhase IDepartment of Transportation
  5. PAR-24-098: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

    Release Date: 01-22-2024Open Date: 02-22-2024 Due Dates: Multiple Close Date: 06-26-2026

    Background A biomarker is a defined characteristic that is measured as an indicator of a normal biological process, pathogenic process, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities are diverse, and can include ‘omics, imaging, behavioral, digital and physiologic endpoints. Because the measurement of the biomarker is integral to defining ...

    SBIRPhase I/Phase IIDepartment of Health and Human ServicesNational Institutes of Health
  6. 24-NH6: Anchor Design for Universal Docking Interface Geometry

    Release Date: 02-08-2024Open Date: 02-08-2024Due Date: 03-07-2024Close Date: 03-07-2024

    24-NH6 FY24.1 DOT SBIR Solicitation Department of Transportation ...

    SBIRPhase IDepartment of Transportation
  7. 8.3: Animal Production and Protection

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Animal Production and Protection topic area aims to develop innovative, marketable technologies that will provide significant benefit to the production and protection of agricultural animals.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  8. 8.7: Aquaculture

    Release Date: 11-14-2023Open Date: 11-14-2023Due Date: 03-26-2024Close Date: 03-26-2024

    The Aquaculture topic area aims to develop new technologies that will enhance the knowledge and technology base necessary for the expansion of the domestic aquaculture industry as a form of production agriculture.

    SBIR/STTRPhase IIDepartment of AgricultureNational Institute of Food and Agriculture
  9. RFA-TR-24-001: Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

    Release Date: 12-01-2023Open Date: 12-04-2023 Due Dates: Multiple Close Date: 03-16-2024

    While there are thousands of rare diseases, the number of underlying etiologies is much smaller. Moreover, many disease etiologies underlie multiple traditional diseases. This is most readily seen for rare monogenic diseases, where the most common etiologies include premature termination codons, protein misfolding, and abnormal RNA splicing. Other examples of rare disease shared molecular etiologi ...

    SBIRPhase IIDepartment of Health and Human ServicesNational Institutes of Health
  10. 24-PH5: Biodegradable Casting for Fireworks

    Release Date: 02-08-2024Open Date: 02-08-2024Due Date: 03-07-2024Close Date: 03-07-2024

    24-PH5 FY24.1 DOT SBIR Solicitation Department of Transportation ...

    SBIRPhase IDepartment of Transportation
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