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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 10421 - 10430 of 11231 results
  1. RFA-DK-11-: Small Business Innovation Research to Develop New Therapeutics and Monitoring Technologies for Type 1 Diabetes (T1D) Towards an Artificial Pancreas

    Release Date: 09-20-2011Open Date: 10-23-2011Due Date: 11-24-2011Close Date: 11-24-2011

    Type 1 diabetes (T1D) results from the autoimmune destruction of the insulin-producing cells of the pancreatic islets of Langerhans and affects more than one million Americans, usually with onset in childhood or young adulthood. The disease markedly impairs quality of life and shortens lifespan primarily through premature mortality.  T1D is associated with numerous complications including bli ...

    SBIR Department of Health and Human Services
  2. 1: Enhancing Access to the Radio Spectrum (EARS)

    Release Date: 09-07-2011Open Date: 10-17-2011Due Date: 11-17-2011Close Date: 11-17-2011

      The fundamental mission of NSF is to promote discoveries and to advance education across the frontiers of knowledge in science and engineering. Consistent with that mission, NSF encourages and supports a wide range of proposals from the research and education community and from the private small business sector. These proposals are reviewed under NSF's merit review criteria, which cov ...

    STTR National Science Foundation
  3. 1: NATIONAL CANCER INSTITUTE (NCI)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      The NCI is the Federal Government’s principal agency established to conduct and support cancer research,  training, health information dissemination, and other related programs. As the effector of the National Cancer  Program, the NCI supports a comprehensive approach to the problems of cancer through intensive investigation  in the cause, diagnosis, prevention, ...

    SBIR Department of Health and Human Services
  4. 255 : Development of Anticancer Agents

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      The short term goal of this SBIR contract topic is to support small businesses that are developing novel candidate  therapeutic agents of interest. The scope of work may include structure activity relationships (SAR), medicinal  chemistry and formulation, animal efficacy testing, pharmacokinetic, pharmacodynamic, and toxicological studies,  as well as production of GM ...

    SBIR Department of Health and Human Services
  5. 277: Development of Companion Diagnostic

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      Recently, the demand for companion diagnostics has greatly increased with the recognition that matching the right patient to the right drug can improve patient care and may decrease health care costs. More than a dozen companion diagnostic tests have been approved by the FDA to guide the prescription of products in oncology, cardiovascular disease, and infectious disease. Among them, t ...

    SBIR Department of Health and Human Services
  6. 291: Development of Radiation Modulators For Use During Radiotherapy

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      Radiotherapy is employed in the treatment of over half of all cancer patients. Many of those patients however, may suffer some adverse effects from this therapy during and/or after treatment. In addition, in approximately half of the patients treated with curative intent, the tumors recur. Enhancing specific tumor killing and minimizing normal tissue damage from radiotherapy would improve ...

    SBIR Department of Health and Human Services
  7. 300: Reformulation of Cancer Therapeutics using Nanotechnology

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      The design of novel therapies and drug delivery systems for cancer is being enabled by nanotechnology. Nanoscale devices carrying therapeutic payloads and delivered within close proximity of the tumor in vivo will play a significant role in increasing the effectiveness of the treatment while decreasing severity of side effects. Such techniques would be highly relevant, particularly for or ...

    SBIR Department of Health and Human Services
  8. 301: Probing Tumor Microenvironment Using In Vivo Nanotechnology-based Sensors

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      Biological fluids and tissue biopsies provide important information with respect to a diagnosis of cancer and to efficacy of its treatment. The collection of both (especially the biopsy) is invasive and can be achieved only in single time points with limited frequency. The analysis of biological fluids (blood, urine), which are easier to collect, do not provide for direct representation o ...

    SBIR Department of Health and Human Services
  9. 306: Development of Innovative Algorithms for Processing & Analysis of In Vivo Images

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      Image processing algorithms are increasingly important as imaging and image-guided intervention technologies become critical in screening, diagnosis, staging, treatment and monitoring of cancer patients. The use of in vivo imaging modalities such as MRI, X-ray, CT, Positron Emission Tomography, Nuclear Medicine, Ultrasound, Optical Coherence Tomography, and Photo-acoustic imaging, as well ...

    SBIR Department of Health and Human Services
  10. 307: Novel Imaging Agents to Expand the Clinical Toolkit for Cancer Diagnosis, Staging, and Treatment

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

      Medical imaging plays a key role in clinical management of cancer patients. Cancer imaging agents are used in conjunction with medical imaging equipment, and, by highlighting the contrast between normal and malignant tissues, they allow the collection of information on cancer presence, spread, and metabolism. Recent scientific advances in nanotechnology, radiochemistry, reporter gene im ...

    SBIR Department of Health and Human Services

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