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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17031 - 17040 of 18922 results
  1. 016: Improving Data, Improving Care, Making it Count

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: The number of people affected by complex childhood rare conditions (CCRC), such as spina bifida (SB), is estimated to be 1/1500 globally. While the prevalence of these conditions is low, they have high impact in terms of health care costs and impact on the family and the community. Reliable and valid clinical data are scarce and insufficient to identify and evaluate clinical practices ...

    SBIRPhase IDepartment of Health and Human Services
  2. 017: Smartphone Application for Global Birth Defects Surveillance

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: Every year approximately 8 million children are born worldwide with severe birth defects. Currently, data about the magnitude of birth defects prevalence in low and middle income countries are either nonexistent or severely underestimated, creating difficulties for health strategic planners to convince policy makers of the burden and the public health impact of birth defects in their c ...

    SBIRPhase IDepartment of Health and Human Services
  3. 033: A Mobile Phone Application (“App”) for Advancing Teen Pregnancy Prevention

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: The teen birth rate in the US remains high, particularly among racial/ethnic minorities compared with many other industrialized nations. The adverse consequences of teen pregnancy are substantial at individual, family, and community levels. A range of innovative tools and interventions is needed to foster an environment that enables teens to experience better reproductive health. In 20 ...

    SBIRPhase IDepartment of Health and Human Services
  4. 003: Development of Nanoparticle Dengue Diagnostic Tests

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: Dengue is a major public health problem in global tropical and subtropical areas. Primary prevention of this mosquito vector-borne (transmitted) disease is limited because vaccines are only in the late-stage development phase and vector control has been thus far unsuccessful. Dengue presents as an acute febrile illness often without signs or symptoms that differentiate it from other co ...

    SBIRPhase IDepartment of Health and Human Services
  5. 004: Development of Tests in a Standardized Kit Format for Diagnosis of Arboviral Infections in Resource-Limited, Primary Health Care Setting

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: Arthropod-borne virus infections may present with clinical symptoms similar to those of other bacterial or viral infections, such as a flu-like illness, encephalitis, or polio-like myelitis. Laboratory diagnosis is essential to determine etiology and calculate disease burden in order to guide treatment and control strategies, particularly if there is an effective vaccine available, suc ...

    SBIRPhase IDepartment of Health and Human Services
  6. 005: Reducing Antimicrobial Resistance through Improved use of Laboratory Testing Information in Healthcare Facilities

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: The reduction and eventual elimination of healthcare-associated infections (HAIs) and the combatting of antibiotic resistance in the pathogens causing these infections are national public health priorities as demonstrated in Department of Health and Human Services (HHS) national action plans. Public reporting of HAIs by hospitals using the National Healthcare Safety Network (NHSN) is m ...

    SBIRPhase IDepartment of Health and Human Services
  7. 034: Development of Biomedical Devices to Elicit Durable Protective Immunity against HIV

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: Substantial progress has been made recently towards identifying effective HIV prevention strategies. The RV144 trial demonstrated that an HIV vaccine comprised of a recombinant ALVAC prime + gp120 boost regimen was partially efficacious (VE=31.2%), although it’s protective effects waned over the study period and study volunteers faced barriers related to transportation to clinic for ...

    SBIRPhase IDepartment of Health and Human Services
  8. 035: Development of a Portable Multiplex Assay for Determination of Recent HIV-1 Infection

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: The estimation of HIV incidence, or the rate of new infections in a population, is an important public health indicator that provides valuable information on the growth of the epidemic and the efficacy of various intervention strategies. Within the past 15 years, a new strategy for estimating HIV incidence has been employed based on the observation that certain biomarkers (mainly HIV-s ...

    SBIRPhase IDepartment of Health and Human Services
  9. 036: Testing the Efficacy of Combination HIV Prevention Strategies in Nonhuman Primates

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: Although substantial progress has been made to identify new biomedical HIV prevention strategies, including topical and oral antiretroviral drug pre-exposure prophylaxis (PrEP) regimens and vaccines, they are not yet approved for general use. However, these preventions (or related derivatives) are likely to be implemented widely in upcoming years. The identification of HIV preventions ...

    SBIRPhase IDepartment of Health and Human Services
  10. 025: Development of an Inactivated Rotavirus Vaccine for Use in Global Immunization

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: The currently licensed oral rotavirus vaccines Rotarix™ and Rotateq™ are effective in reducing cases of severe diarrhea among children in high and middle income countries, but are significantly less effective in low income countries. In addition, both vaccines are associated with a low risk of diarrhea and intussusception among infants who receive the first dose of vaccine. To impr ...

    SBIRPhase IDepartment of Health and Human Services
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