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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17051 - 17060 of 18924 results
  1. 3.08: Health Services Research on Alcohol-Related Problems

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    Research projects are sought that will expand knowledge and improve delivery of alcohol treatment and prevention services. The research objectives include, but are not limited to, the effects of organizational structures and financing mechanisms on the availability, accessibility, utilization, delivery, content, quality, outcomes, and costs of alcohol treatment services. Objectives also include st ...

    STTRPhase IDepartment of Health and Human Services
  2. 3.09: Fetal Alcohol Spectrum Disorder (FASD) and Alcohol-Related Birth Defects

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    FASD is the collective term for the broad array of documented adverse effects resulting from in utero alcohol exposure. The most serious of these is fetal alcohol syndrome (FAS), a devastating developmental disorder characterized by craniofacial abnormalities, growth retardation, and nervous system impairments that may include mental retardation. Other diagnostic categories include partial FAS, al ...

    STTRPhase IDepartment of Health and Human Services
  3. 3.10: Alcohol Use and HIV, HBV, or HCV Infection

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    Alcohol use, including hazardous drinking, by persons infected with HIV, HBV, and HCV, is quite common in the United States. Alcohol consumption is widely acknowledged as a co-factor in the sexual transmission, susceptibility to infection, and progression of the infectious diseases. However, detailed relationships between alcohol use and viral infections, diseases progression, antiretroviral thera ...

    STTRPhase IDepartment of Health and Human Services
  4. 3.11: Research Tools

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    The NIAAA supports the development of new or improved tools to enhance the ability to conduct alcohol-related laboratory studies on humans and animals and to more effectively analyze data from large databases. Examples include transgenic animal models, cell lines, new ligands for neuroimaging, and simulators of alcohol impairment. Areas that may be of interest to small businesses include, but are ...

    STTRPhase IDepartment of Health and Human Services
  5. 3.12: Development of Biomolecular Signatures of Alcohol Exposure and Alcohol-induced Tissue Injury

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    Acute and chronic alcohol consumption leads to health-related complications and ultimately to significant societal costs. Quantitative and qualitative markers of high-risk drinking behavior and alcohol-induced tissue damage would greatly improve medical efforts to recognize and treat alcohol-related disorders. Traditional biomarkers currently in clinical use lack specificity, sensitivity, and accu ...

    STTRPhase IDepartment of Health and Human Services
  6. 3.13: Clinical Testing of Biochemical Markers

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    The development of effective biochemical markers represents a powerful means for early diagnosis and treatment of alcohol dependent/abuse patients and for the identification of individuals who have a predisposition for alcoholism. There are two different types of biochemical markers: trait markers and state markers. Trait biomarkers have the ability to detect inborn characteristics of individual ...

    STTRPhase IDepartment of Health and Human Services
  7. 3.14: Stem Cell Research for Alcohol-induced Disorders

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    Stem cells are master cells in the body and they have the remarkable potential to develop into many different cell types. Stem cells may become a renewable source of replacement cells to treat alcohol related diseases. They can also be used to study disease processes, and to develop new and more effective drugs. Recent research progress on stem cells has offered great opportunities to study cond ...

    STTRPhase IDepartment of Health and Human Services
  8. 3.15: Real-time Detection of Neurochemical Changes in Response to Alcohol Drinking

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    Many pharmacological mechanisms of ethanol action in the brain are mediated by time-dependent neurochemical events in multiple brain regions. Despite great progress in identifying ethanol’s neurochemical actions, we do not fully know how neurochemicals change in real time following ethanol administration and drinking (acute and chronic). Multidimensional measurement of neurochemical change (i.e. ...

    STTRPhase IDepartment of Health and Human Services
  9. 3.16: Develop Network Pharmacology Strategy for Preclinical Medication Development

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    The frequent failure of using highly selective drugs for disease treatment has challenged the concept of “one gene, one drug and one disease” and led to the emergence of a new paradigm, network pharmacology, as a drug development and treatment strategy. This strategy combines the knowledge of biological networks with multiple drug targets to simultaneously regulate multiple pathways perturbed ...

    STTRPhase IDepartment of Health and Human Services
  10. 3.17: Other Research Topic(s) Within the Mission of the Institute

    Release Date: 01-31-2012Open Date: 03-05-2012Due Date: 01-08-2013Close Date: 01-08-2013

    For additional information on research topics, contact: Gary J. Murray, Ph.D. National Institute on Alcohol Abuse and Alcoholism 5635 Fishers Lane, Room 2037 Bethesda, MD 20892-9304 For Federal Express delivery, use: Rockville, MD 20852-1705 Phone: 301-443-9940 Email: Gary.Murray@nih.gov For administrative and business management questions, contact: Ms. Judy Fox Grants Mana ...

    STTRPhase IDepartment of Health and Human Services
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