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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17101 - 17110 of 18912 results
  1. 004: Assay Development for High-Throughput Screening of Chemicals of Toxicological Concern

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Adverse human health outcomes – a.k.a., “toxicity” – caused by pharmaceutical or environmental compounds are a major cause of drug development failure and public health concern. Methods to evaluate the potential of chemical compounds to induce toxicity are based largely on animal testing, are low-throughput and expensive while giving little insight into mechanisms of toxicity, and have not ...

    SBIRPhase IDepartment of Health and Human Services
  2. 072: New Methods to Detect and Assess Myocardial Fibrosis

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Myocardial fibrosis is a crucial marker of adverse cardiac remodeling. Research suggests a strong correlation between the extent of myocardial fibrosis and adverse myocardial remodeling that occurs after ischemic injury or during the progression of cardiomyopathies and heart failure. Diffuse myocardial fibrosis is thought to provide a high-risk substrate for the development of atrial and v ...

    SBIRPhase IDepartment of Health and Human Services
  3. 073: Evaluating Obstructive Sleep Apnea Dental Device Treatment Compliance

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary As a therapeutic option, an array of existing oral appliances are approved for the medical treatment of snoring and mild to moderate obstructive sleep apnea but lack specific capabilities necessary to fulfill regulatory requirements and conduct population-based effectiveness research. Integration of oral appliance and electronic monitoring technologies is needed to develop enhanced oral de ...

    SBIRPhase IDepartment of Health and Human Services
  4. 074: Improving Safety and Efficacy of Red Blood Cells for Transfusion

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Red blood cell (RBC) products for transfusion undergo metabolic and physical changes in both the cellular and plasma fractions during storage (RBCs can be stored up to 42 days currently) which may be associated with non-infectious risks and reduced tissue oxygenation capacity. The changes that occur during storage have been referred to in the literature as the RBCs “storage lesion”. Ma ...

    SBIRPhase IDepartment of Health and Human Services
  5. 075: Dedicated Pediatric Cardiac MRI Receive Coils

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Clinical MRI systems use local surface receive devices (coils) to provide optimized signal to noise and enable fast imaging using parallel imaging techniques. These surface coils are designed for adult patients and function poorly for pediatric patients. Pediatric coils are targeted at a certain age group and due to the wide range of pediatric patient sizes (from neonates to preadolescents ...

    SBIRPhase IDepartment of Health and Human Services
  6. 076: MRI Myocardial Biopsy Forceps

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Endomyocardial biopsies are performed approximately 10,000 times each year worldwide. The procedure suffers large anatomic sampling error because of no current appropriate image guidance. Endomyocardial biopsy is currently performed without targeting, whether under X-ray or ultrasound guidance. This may account for the known low diagnostic yield and high sampling error. Image-guided myocar ...

    SBIRPhase IDepartment of Health and Human Services
  7. 077: Passive MRI Guidewire

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary MRI-guided catheter procedures can avoid radiation and may allow surgery to be avoided in a range of applications. A safe clinical guidewire is not commercially available. A complex “active” electronic MRI guidewire is being developed by DIR. However, a more simple and versatile “passive” MRI guidewire also is valuable to be used as part of multi-step procedures (such as catheter e ...

    SBIRPhase IDepartment of Health and Human Services
  8. 078: Transthoracic Cardiac Access Ports and Closure Devices

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Implanting large appliances, such as mitral valve replacement, currently requires cardiac surgery and cardiopulmonary bypass. Minithoracotomy access remains high risk. NHLBI has shown early feasibility of direct transthoracic large-port access to the beating heart, and effective closure using nitinol appliances in animal models. The objective of this contract solicitation is to support the ...

    SBIRPhase IDepartment of Health and Human Services
  9. 079: Bioabsorbable Stents for Pediatric Pulmonary Artery Stenosis and Aortic Coarctation

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Mechanical stents to relieve obstructive cardiovascular lesions could have great utility in pediatric cardiology, but are unsuitable for small children. Commercially available stents limit vessel growth and require future surgical removal. Absorbable stents might revolutionize the treatment of congenital heart disease in children. Small children require small delivery systems for devices t ...

    SBIRPhase IDepartment of Health and Human Services
  10. 080: Fluorescent Nanodiamonds for In Vitro and In Vivo Biological Imaging

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary There is a need to develop a biocompatible fluorescent label that never photobleaches or blinks, and that is brighter than commonly used dyes. Fluorescent nanodiamonds (FNDs) are 10 to 100 nm sized biocompatible particles with indefinite photo-stability that make them superior imaging probes for a wide range of applications. Whereas organic dyes and quantum dots are neither biocompatible n ...

    SBIRPhase IDepartment of Health and Human Services
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