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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17131 - 17140 of 18150 results
  1. 066: Haptoglobin Treatment to Reduce Complications of Sickle Cell Disease

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The release of hemoglobin into the circulation contributes to morbidity and mortality in intense hemolytic states such as sickle cell disease (SCD). Free hemoglobin related vascular reactivity, potentially through nitric oxide scavenging and oxidative stress associated with the iron moiety of heme likely result in pulmonary arterial hypertension, stroke and the acute chest syndrome in SCD. A gluco ...

    SBIRPhase IDepartment of Health and Human Services
  2. 067: Transmit-receive Surface Array Coils for MRI of Patients with Internal Conductive Devices

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Magnetic resonance imaging (MRI) has the potential to guide non-surgical cardiovascular interventional procedures because it can visualize soft tissue, guide positioning of therapeutic devices, and assess treatment outcome, all without ionizing radiation. To ensure that such procedures can be carried out effectively and safely it is essential to have devices (catheters, guidewires, etc.) that have ...

    SBIRPhase IDepartment of Health and Human Services
  3. 068: Multilayer-coated Gratings for Phase-Contrast Computed Tomography

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    In the United States computed tomography (CT) currently accounts for approximately 15% of all diagnostic imaging procedures. The number of CT scans has seen a threefold increase in the two decades leading to 2007 due to its unique capabilities. A CT scan produces high resolution, volumetric rendition of internal organs in a short period. CT scanners are relatively compact and economic to operate a ...

    SBIRPhase IDepartment of Health and Human Services
  4. 069: Wireless Physiologic Telemetry for Interventional MRI

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Magnetic resonance imaging (MRI) has potential to revolutionize minimally invasive surgery and interventional procedures by affording improved tissue visualization without conventional surgical incisions. Many such procedures will be conducted under both X-ray and MRI guidance. Such procedures require high fidelity hemodynamic recording of physiological signals such as electrocardiography and inva ...

    SBIRPhase IDepartment of Health and Human Services
  5. 070: Bioabsorbable Stents for Pediatric Pulmonary Artery Stenosis and Aortic Coarctation

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Mechanical stents to relieve obstructive cardiovascular lesions could have great utility in pediatric cardiology, but are unsuitable for small children. Commercially available stents limit vessel growth and require future surgical removal. Absorbable stents might revolutionize the treatment of congenital heart disease in children. Small children require small delivery systems for devices that are ...

    SBIRPhase IDepartment of Health and Human Services
  6. 071: Electrophysiologic Catheters for Interventional MRI Ablation of Ventricular Tachycardia

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Catheter-based ablation therapy is used to treat cardiac rhythm disorders. MRI may have value in targeting and assessing ablation lesions interactively during catheter based cardiac electrophysiology (EP) procedures. Real-time MRI EP ablation may be especially attractive to ablate mid-myocardial targets causing ventricular tachycardia in adults and children. While technically feasible, there are ...

    SBIRPhase IDepartment of Health and Human Services
  7. 4: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The NIAAA supports research on the causes, prevention, control, and treatment of the major health problems of alcohol abuse, alcoholism, and alcohol-related disorders. Through its extramural research programs, the NIAAA funds a wide range of basic and applied research to develop new and/or improved technologies and approaches for increasing the effectiveness of diagnosis, treatment, and prevention ...

    SBIRPhase IDepartment of Health and Human Services
  8. 044: Development of Novel Compounds to Treat Alcohol Use Disorders

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Efforts to develop medications for alcohol use disorders have expanded rapidly in recent years. Developing novel compounds for alcohol treatment is high priority for NIAAA Medications Development Program. Three agents directed at the addictive behavior in the use of alcohol —disulfiram, naltrexone, and acamprosate—are now approved for use in the United States and many other countries. Recently ...

    SBIRPhase IDepartment of Health and Human Services
  9. 5: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The NIDDK supports research in diabetes, endocrinology and metabolic diseases; digestive diseases and nutrition; and kidney, urologic and hematologic diseases. For additional information about areas of interest to the NIDDK, please visit our home page at http://www.niddk.nih.gov.

    SBIRPhase IDepartment of Health and Human Services
  10. 075: A Low Molecular Weight Thyroid-Stimulating Hormone Receptor Agonist for Thyroid Cancer (NIH TT)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    NIDDK investigators have discovered and are evaluating the first potent and efficacious small molecule agonist of the thyroid-stimulating hormone (TSH, thyrotropin) receptor (TSHR) that has potential for clinical application in patients with thyroid cancer. This agonist drug is intended for use in patients for 2-5 days at a time following thyroidectomy and at subsequent intervals after initial tre ...

    SBIRPhase IDepartment of Health and Human Services
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