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test bed aircraft, and the simulation and loads laboratories. A key component of ensuring a test facility's long-term viability is to implement and continually improve on the efficiency and effectiveness of that facility's operations along with developing new technologies to address the nation's future aerospace challenges. To operate a facility in this manner requires the use of state-of-the-art test technologies and test techniques, creative facility performance capability enhancements, and novel means of acquiring test data.

The Aviation Safety Program conducts fundamental research and technology development of known and predicted safety concerns as the nation transitions to the Next Generation Air Transportation System (NextGen). Future challenges to maintaining aviation safety arise from expected significant increases in air traffic, continued operation of legacy vehicles, introduction of new vehicle concepts, increased reliance on automation, and increased operating complexity.

NASA is concerned with new and innovative methods for detection, identification, evaluation, and monitoring of in-flight hazards to aviation. NASA seeks to foster research and development that leads to innovative new technologies and methods, or significant improvements in existing technologies, for in-flight hazard avoidance and mitigation. Technologies may take the form of tools, models, techniques, procedures, substantiated guidelines, prototypes, and devices.

NASA is concerned with the prevention of encounters with hazardous in-flight conditions and the mitigation of their effects when they do occur. Under this subtopic, proposals are invited that explore new and dramatically improved technologies related to inflight airframe and engine icing hazards for manned and unmanned vehicles. Technologies of interest should address the detection, measurement, a ...

The NINDS Translational Research Program is specifically focused on pre-clinical therapy development necessary to begin clinical testing of therapeutic candidates for neurological disorders. This program supports the pre-clinical development of drugs, biologics, and devices including activities from the identification of a therapeutic lead to Investigational New Drug (IND) or Investigational Devic ...

The scope of the Phase I portion of a Fast-Track in the program includes all activities in the pre-clinical therapy development pipeline, and the Phase I can be structured in any way necessary to support subsequent pre-clinical development tasks during the Phase II project. However, the Phase II awards in the program support milestone-driven projects that begin with identified candidate therapeuti ...

The scope of a Phase II award in the program is the same whether it is based on a previously successful Phase I in the regular SBIR program or if it is part of a Fast-Track application. For entry to the program, projects must have one or more identified therapeutic leads and convincing proof-of-principle on efficacy demonstrated in credible models of the disease or against defined disease targets ...

The NINDS Cooperative Program in Translational Research Small Business Awards provides funding through the U44 cooperative agreements mechanism. As a cooperative agreement, implementation will involve participation of NINDS program staff in the planning and execution of these therapy-directed projects. The U44 cooperative agreements support translational research projects that are focused on a sin ...

The objective of this subtopic is to develop information technologies that enable robots to better support planetary exploration. Intelligent robots are already at work in all of NASA's Mission Directorates and will be critical to the success of future exploration missions.

This subtopic addresses advanced control-oriented techniques for aeroservoelastic (ASE) flight systems including distributed network sensor systems, modeling, simulation, optimization and stabilization methods of ASE systems to actively and/or adaptively control wing geometry, vibration, gust/turbulence response, static/dynamic loads, and other aeroelastic (AE) objectives for enhanced aeroservoelastic performance and stability characteristics.Technical elements for these proposals may include: