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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17221 - 17230 of 19124 results
  1. 021: Aerosolized Delivery of Anti-Tubercular Drugs

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background Many currently existing drugs for the treatment of TB, especially MDR TB are moderately potent, show restrictions with absorption or oral bioavailability, and have toxicity profiles that make patient management difficult. Aerosolized delivery offers the potential to bypass these barriers to drug efficacy by achieving high drug concentrations in the infected pulmonary tissue with lower s ...

    SBIRPhase IDepartment of Health and Human Services
  2. 022: Development of Long-Acting Formulations of HIV Anti-Retrovirals

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background Effective treatment of HIV-infected individuals requires strict adherence to a multi-component regimen of antiretroviral agents that currently must be taken daily on a life-long basis. Non-compliance with recommended dosing regimens is a significant factor contributing to the incomplete suppression of HIV and to the development of drug resistance. The development of long-acting formulat ...

    SBIRPhase IDepartment of Health and Human Services
  3. 023: Improved Formulations for Approved First and Second line anti-Tuberculosis (TB) Drugs

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background There is an urgent need to develop alternative formulations of approved first and second line anti-TB drugs for pediatric use and also to simplify administration. There are few child-friendly formulations of pediatric first and second-line anti-TB medications available to practitioners in the US and globally. It is standard practice to cut or crush un-scored adult tablets and administer ...

    SBIRPhase IDepartment of Health and Human Services
  4. 024: Integrated Multiplex Medical Diagnostics Platforms for Infectious Diseases

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background NIAID supports integrated multiplex medical diagnostics platforms capable of simultaneously identifying multiple pathogens in clinical specimens (swabs, sputum, blood, serum, cerebrospinal fluid, urine, stool, etc.). Platforms that provide diagnostic information on potential early, non-specific symptoms and determine pathogen drug sensitivities are of high priority. Project Goal The fi ...

    SBIRPhase IDepartment of Health and Human Services
  5. 023: Neural Interfaces: Improving Functional Outcomes

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary The long term goal of neural interfaces for medical rehabilitation purposes is to replace lost functionality for people with physical disabilities. While great strides have been made in the neuroprosthetics field, the state of the art falls far short of complete restoration of function. For example, there is no consensus on the best modality for extracting signals from the central nervous ...

    SBIRPhase IDepartment of Health and Human Services
  6. 147: A Mobile Application to Help Patients Take their Pill Medications as Prescribed: Improving Medication Adherence

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    It is strongly suggested that proposals adhere to the above budget amounts and project periods. Proposals with budgets exceeding the above amounts and project periods may not be funded. Drugs don’t work in patients who don’t take them. — C. Everett Koop, M.D, former U.S. Surgeon General Medication adherence is described as the extent to which patients take medications as prescribed by their ...

    SBIRPhase IDepartment of Health and Human Services
  7. 148: Products for at-home Deactivation of Psychoactive Prescription Medicines

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Objective: This topic addresses the need to fund research and development activities to promote the commercial development and testing of an inexpensive prescription medicine disposal system that would provide a simple means for patients (prescription drug “end-users” defined by the Drug Enforcement Administration) or members of their household to safely render prescription drugs unusable and ...

    SBIRPhase IDepartment of Health and Human Services
  8. 149: Development of Predictive in vivo Screening Systems for Phenotypic Drug Discovery for Smoking Cessation

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Summary Phenotypic drug discovery is a complement to target-based drug discovery and provides an alternative approach that begins by querying more complex cellular of physiological systems instead of specific targets. The possible advantage resides in the fact that a relevant biological context is interrogated without predisposed bias toward mechanism(s). Thus, an opportunity is created to identif ...

    SBIRPhase IDepartment of Health and Human Services
  9. 150: Video Game Targeting Relapse Prevention in Youth with Substance Use Disorders

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Objective This topic addresses the need for improved relapse rates among adolescent substance abusers. A video game should be designed for substance using adolescents in a commercializable and compelling package, for the purpose of reinforcing and maintaining behavior changes (e.g., skills development) accomplished through a theory-driven and evidence-based therapy. The video game may be compatibl ...

    SBIRPhase IDepartment of Health and Human Services
  10. 003: Diagnostic Needs for Neglected Tropical Diseases (NTD) Programs

    Release Date: 08-15-2012Open Date: 08-15-2012Due Date: 12-03-2012Close Date: 12-03-2012

    Background: Neglected tropical diseases (NTDs) are bacterial and parasitic infections that disproportionately affect poor and marginalized populations around the world. A subset of NTDs, including lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma and intestinal helminth infections, can be targeted effectively through mass chemotherapy. These NTDs are not considered to cause appreciab ...

    SBIRPhase IDepartment of Health and Human Services
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