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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17341 - 17350 of 18147 results
  1. 277: Development of Companion Diagnostic

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Recently, the demand for companion diagnostics has greatly increased with the recognition that matching the right patient to the right drug can improve patient care and may decrease health care costs. More than a dozen companion diagnostic tests have been approved by the FDA to guide the prescription of products in oncology, cardiovascular disease, and infectious disease. Among them, tests of Phil ...

    SBIRPhase IDepartment of Health and Human Services
  2. 291: Development of Radiation Modulators For Use During Radiotherapy

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Radiotherapy is employed in the treatment of over half of all cancer patients. Many of those patients however, may suffer some adverse effects from this therapy during and/or after treatment. In addition, in approximately half of the patients treated with curative intent, the tumors recur. Enhancing specific tumor killing and minimizing normal tissue damage from radiotherapy would improve tumor co ...

    SBIRPhase IDepartment of Health and Human Services
  3. 300: Reformulation of Cancer Therapeutics using Nanotechnology

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The design of novel therapies and drug delivery systems for cancer is being enabled by nanotechnology. Nanoscale devices carrying therapeutic payloads and delivered within close proximity of the tumor in vivo will play a significant role in increasing the effectiveness of the treatment while decreasing severity of side effects. Such techniques would be highly relevant, particularly for organs that ...

    SBIRPhase IDepartment of Health and Human Services
  4. 301: Probing Tumor Microenvironment Using In Vivo Nanotechnology-based Sensors

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Biological fluids and tissue biopsies provide important information with respect to a diagnosis of cancer and to efficacy of its treatment. The collection of both (especially the biopsy) is invasive and can be achieved only in single time points with limited frequency. The analysis of biological fluids (blood, urine), which are easier to collect, do not provide for direct representation of the tum ...

    SBIRPhase IDepartment of Health and Human Services
  5. 306: Development of Innovative Algorithms for Processing & Analysis of In Vivo Images

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Image processing algorithms are increasingly important as imaging and image-guided intervention technologies become critical in screening, diagnosis, staging, treatment and monitoring of cancer patients. The use of in vivo imaging modalities such as MRI, X-ray, CT, Positron Emission Tomography, Nuclear Medicine, Ultrasound, Optical Coherence Tomography, and Photo-acoustic imaging, as well as multi ...

    SBIRPhase IDepartment of Health and Human Services
  6. 307: Novel Imaging Agents to Expand the Clinical Toolkit for Cancer Diagnosis, Staging, and Treatment

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Medical imaging plays a key role in clinical management of cancer patients. Cancer imaging agents are used in conjunction with medical imaging equipment, and, by highlighting the contrast between normal and malignant tissues, they allow the collection of information on cancer presence, spread, and metabolism. Recent scientific advances in nanotechnology, radiochemistry, reporter gene imaging, ca ...

    SBIRPhase IDepartment of Health and Human Services
  7. 308: Automated Collection, Storage, Analysis, and Reporting Systems for Dietary Images

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Current dietary assessment methods and systems largely depend on time and resource intensive self-report and/or recall methods. Accuracy of the assessment is often compromised when diet is assessed via self-report because of the cognitive challenges in recalling or reporting quantities, types, and preparation of foods eaten. Dietary assessment methods that do not rely solely on self-report and rec ...

    SBIRPhase IDepartment of Health and Human Services
  8. 309: Development of Low Cost, Small Sample Multi-Analyte Technologies for Cancer Diagnosis, Prognosis and Early Detection

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Cancer is recognized as a multistep process involving multiple genomic and epigenomic alterations that occur in multiple phases. The complexity of cancer requires multivariate assays for accurate diagnosis, prognosis and treatment monitoring. Recently, two multivariate gene-expression assays, Oncotype DX and MammaPrint, have been developed for determining whether chemotherapy is necessary for brea ...

    SBIRPhase IDepartment of Health and Human Services
  9. 310: Simplified Tissue Microarray Instrument For Clinical and Research Settings (NIH Technology Transfer)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The capacity to present defined, pre-selected samples of archival tissue for immunohistochemical and in situ molecular analysis has revolutionized the development and validation of tissue-based biomarkers in research and clinicalapplication. In the clinical setting, most new diagnoses of cancer use immunohistochemical assays of tissue samples to support the diagnoses, and these immunohistochemical ...

    SBIRPhase IDepartment of Health and Human Services
  10. 311: High Throughput Isolation of Antigen Specific T-cells for Cancer Therapy (NIH Technology Transfer)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The adoptive transfer of autologous tumor reactive T lymphocytes (T cells) can mediate significant tumor regression and long term cures in patients with refractory metastatic cancer. Despite these important clinical findings, adoptive cell transfer has not become widely available for patient treatment. Obtaining tumor infiltrating lymphocytes (TIL), T cells associated with a tumor that can exhibit ...

    SBIRPhase IDepartment of Health and Human Services
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