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NOTE: The Solicitations and topics listed on this site are copies from the various SBIR agency solicitations and are not necessarily the latest and most up-to-date. For this reason, you should visit the respective agency SBIR sites to read the official version of the solicitations and download the appropriate forms and rules.

Displaying 17891 - 17900 of 18922 results
  1. 309: Development of Low Cost, Small Sample Multi-Analyte Technologies for Cancer Diagnosis, Prognosis and Early Detection

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Cancer is recognized as a multistep process involving multiple genomic and epigenomic alterations that occur in multiple phases. The complexity of cancer requires multivariate assays for accurate diagnosis, prognosis and treatment monitoring. Recently, two multivariate gene-expression assays, Oncotype DX and MammaPrint, have been developed for determining whether chemotherapy is necessary for brea ...

    SBIRPhase IDepartment of Health and Human Services
  2. 310: Simplified Tissue Microarray Instrument For Clinical and Research Settings (NIH Technology Transfer)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The capacity to present defined, pre-selected samples of archival tissue for immunohistochemical and in situ molecular analysis has revolutionized the development and validation of tissue-based biomarkers in research and clinicalapplication. In the clinical setting, most new diagnoses of cancer use immunohistochemical assays of tissue samples to support the diagnoses, and these immunohistochemical ...

    SBIRPhase IDepartment of Health and Human Services
  3. 311: High Throughput Isolation of Antigen Specific T-cells for Cancer Therapy (NIH Technology Transfer)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The adoptive transfer of autologous tumor reactive T lymphocytes (T cells) can mediate significant tumor regression and long term cures in patients with refractory metastatic cancer. Despite these important clinical findings, adoptive cell transfer has not become widely available for patient treatment. Obtaining tumor infiltrating lymphocytes (TIL), T cells associated with a tumor that can exhibit ...

    SBIRPhase IDepartment of Health and Human Services
  4. 312: Generation and Qualification of Site-specific Post-translationally Modified Proteins for Use as Calibrators in Pharmacodynamic (PD) Assays

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    NCI is committed to developing clinically useful biomarker tests that identify critical molecular targets within a patient's tumor, which can provide drug sensitivity, resistance, and real-time response information. For this SBIR topic, NCI requests that qualified small businesses submit proposals to aid the development of robust, quantitative pharmacodynamic (PD) immunoassays. Specifically, t ...

    SBIRPhase IDepartment of Health and Human Services
  5. 2: NATIONAL CENTER FOR RESEARCH RESOURCES (NCRR)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The National Center for Research Resources (NCRR) provides laboratory scientists and clinical researchers with the tools and training they need to understand, detect, treat, and prevent a wide range of diseases. NCRR supports all aspects of clinical and translational research, connecting researchers, patients, and communities across the nation. This support enables discoveries made at a molecular ...

    SBIRPhase IDepartment of Health and Human Services
  6. 015: Development of an Integrated Automated High Throughput Platform for Large-Scale Genetic and Therapeutic Screening in Zebrafish

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Non-mammalian models, such as zebrafish, have emerged as powerful model organisms due to the availability of a wide array of species-specific genetic techniques, along with its short development time, fecundity and small size. For zebrafish larvae, their small size and optical clarity allows the use of powerful optical techniques that enable precise cellular visualization within the living animal, ...

    SBIRPhase IDepartment of Health and Human Services
  7. 3: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI)

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    The NHLBI plans, conducts, fosters, and supports an integrated and coordinated program of basic research, clinical investigation, and trials, observational studies, and demonstration and education projects. The Institute’s mission includes studies related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, blood, sleep disorders, and blood resources management. Stud ...

    SBIRPhase IDepartment of Health and Human Services
  8. 044: Development of Induced Pluripotent Stem (iPS) Cell Lines for Use in Cell-based Bioassays

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Recent technology enabling the production of induced Pluripotent Stem (iPS) cell lines has created significant opportunities for the development of new cell lines as products for use as cell-based bioassays such as in screening assays. The technology provides the means to expand the iPS cell lines to the numbers needed for bioassay applications and will enable the derivation of cell lines with spe ...

    SBIRPhase IDepartment of Health and Human Services
  9. 058: Novel Technologies for Powering Ventricular Assist Devices

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Because the heart transplant donor pool in the United States is less than 2,500/year, ventricular assist devices (VADs) are the only realistic option for many late-stage heart failure patients. Currently, each year 2,000-5,000 receive VADs to bridge them to a heart transplant or as permanent (i.e. “destination”) therapy. However, the VADs currently available rely upon batteries that, despite r ...

    SBIRPhase IDepartment of Health and Human Services
  10. 063: Reagents for Studying Human Lung Cell Biology and Cellular Function

    Release Date: 08-25-2011Open Date: 08-25-2011Due Date: 11-07-2011Close Date: 11-07-2011

    Approximately half of the 44 cells that comprise the human respiratory tract still remain partially identified and their function(s) is incompletely understood (Franks et. al. Proc Am Thorac Soc 2008; 5: 763-6)). Suitable technologies are available to identify, sort, purify, culture, and determine cell surface markers or other unique identifying features that permit individual characterization of ...

    SBIRPhase IDepartment of Health and Human Services
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