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The NINDS Translational Research Program is specifically focused on pre-clinical therapy development necessary to begin clinical testing of therapeutic candidates for neurological disorders. This program supports the pre-clinical development of drugs, biologics, and devices including activities from the identification of a therapeutic lead to Investigational New Drug (IND) or Investigational Devic ...

The scope of the Phase I portion of a Fast-Track in the program includes all activities in the pre-clinical therapy development pipeline, and the Phase I can be structured in any way necessary to support subsequent pre-clinical development tasks during the Phase II project. However, the Phase II awards in the program support milestone-driven projects that begin with identified candidate therapeuti ...

The scope of a Phase II award in the program is the same whether it is based on a previously successful Phase I in the regular SBIR program or if it is part of a Fast-Track application. For entry to the program, projects must have one or more identified therapeutic leads and convincing proof-of-principle on efficacy demonstrated in credible models of the disease or against defined disease targets ...

The NINDS Cooperative Program in Translational Research Small Business Awards provides funding through the U44 cooperative agreements mechanism. As a cooperative agreement, implementation will involve participation of NINDS program staff in the planning and execution of these therapy-directed projects. The U44 cooperative agreements support translational research projects that are focused on a sin ...

Background The physical impact of Hurricane Katrina occurred over hours and days. The mental health effects of this large-scale, traumatic event may be fully evident only over weeks, months, years, and, perhaps, generations. The types of trauma from such events are many, diverse, and complex. The affected populations, including both direct victims and those secondarily involved (e.g., first resp ...

On February 26, 2004, Executive Order 13329 (http://a257.g.akamaitech.net/7/257/2422/14mar20010800/edocket.access.gpo.gov/2004/pdf/04-4436.pdf) was signed by President George W. Bush requiring SBIR/STTR agencies, to the extent permitted by law and in a manner consistent with the mission of the Department, to give high priority within the SBIR and STTR programs to manufacturing-related research and ...

On February 26, 2004, Executive Order 13329 (http://a257.g.akamaitech.net/7/257/2422/14mar20010800/edocket.access.gpo.gov/2004/pdf/04-4436.pdf) was signed by President George W. Bush requiring SBIR/STTR agencies, to the extent permitted by law and in a manner consistent with the mission of the Department, to give high priority within the SBIR and STTR programs to manufacturing-related research and ...

The SBIR program, as established by law, is intended to meet the following goals: stimulate technological innovation in the private sector; strengthen the role of small business in meeting Federal research or research and development (R/R&D) needs; increase the commercial application of Federally-supported research results; foster and encourage participation by socially and econom ...

The STTR program, as established by law, is intended to stimulate a partnership of ideas and technologies between innovative small business concerns (SBCs) and research institutions through Federally-funded research or research and development (R/R&D). By providing awards to SBCs for cooperative R/R&D efforts with research institutions, the STTR program assists the small business and research comm ...

Background Liver and biliary diseases affect Americans of all ages and all walks of life. Collectively liver and biliary diseases rank in the top 10 causes of mortality in the United States. Chronic liver diseases affect between 5 and 10 percent of Americans and account for 1 to 2 percent of deaths in the United States. Gallbladder disease affects an estimated 20 million Americans and causes con ...