Funding Opportunities

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The SBA Help Desk is closed and will re-open on Monday, April 20th. All requests submitted to sba.sbir.support@reisystems.com will be responded to on Monday, April 20th in the order received.

Topics and solicitations are known by many names including Request for Proposals (RFP), Funding Opportunity Announcement (FOA), Broad Agency Announcement (BAA), or simply Topic/Solicitation. No matter what it's called, they outline specific rules and guidance on how to prepare a response, also called an application or a proposal.

Funding Planner

Participating Agencies post SBIR/STTR funding opportunities on a regular periodic basis throughout the year. Some agencies have multiple solicitations throughout the year, while others may only have one solicitation release each year. Once you identify a relevant agency to target, learn more about that specific agency's process.

Graphic: displays award timelines related to award years and agencies. — Funding planner with estimated dates. All agencies have a 45 day lead in period. DHS is from September to October 2025, DoD has multiple dates, DOE is from May to August, and September to January, DOT is February to April, ED is November to January 2026, EPA is April to June, HHS is April to May, June to August, and September to November, NASA is February to April, May to June, and August to October, NOAA is November to February 2026, NSF is January to April, June to August, and USDA is June to August.

Note: Department of Defense releases are the first Wednesday of each month, and closes the last Wednesday of the following month (e.g., opens 03/26/2025, closes 04/23/25)

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Showing 161-170 of 170 results

NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required)

Open Release Date: November 30, 2023 Open Date: December 1, 2023 Close Date: January 8, 2027

Purpose...

SBIR

Phase II

Interactive Digital Media (IDM) Biomedical Science Resources for Pre-College Students and Teachers (SBIR) (R43/R44 Clinical Trial Not Allowed)

Open Release Date: June 15, 2023 Open Date: August 5, 2023 Close Date: September 6, 2025

Interactive Digital Media (IDM) refers to products and services on digital computer-based systems which respond to the user’s actions by presenting content in the form of text, images, animations, audios, videos, and video games. These products and services...

SBIR

BOTH

SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1 Clinical Trial Required)

Open Release Date: July 12, 2023 Open Date: August 5, 2023 Close Date: September 6, 2025

The NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs have provided the small business community with critical seed funding to support the development of a wide variety of technologies that benefit society....

SBIR

Phase II

SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)

Open Release Date: July 12, 2023 Open Date: August 5, 2023 Close Date: September 6, 2025

SBIR

Phase II

Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

Open Release Date: April 18, 2023 Open Date: May 6, 2023 Close Date: June 7, 2025

Purpose...

SBIR

BOTH

Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (UT1/UT2) Clinical Trial Not Allowed

Open Release Date: April 18, 2023 Open Date: May 6, 2023 Close Date: June 7, 2025

Purpose...

STTR

BOTH

HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)

Open Release Date: January 3, 2023 Open Date: March 5, 2023 Close Date: September 6, 2025

The goal of this FOA is to support the commercialization of SBIR/STTR-funded pain management technologies through the addition of an experienced entrepreneur within small business leadership teams and by supporting private fundraising and partnership...

SBIR

Phase II

Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)

Open Release Date: June 21, 2022 Open Date: December 5, 2022 Close Date: September 6, 2025

Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer’s Project Act and, the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and...

STTR

BOTH

Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

Open Release Date: June 21, 2022 Open Date: December 5, 2022 Close Date: September 8, 2025

Recommendations and milestones for Alzheimer's disease (AD) and AD-related dementias (ADRD) research from the National Alzheimer’s Project Act and the 2015, 2018, 2019, and 2021 Alzheimer's Disease Research Summits present a wide range of research and...

SBIR

BOTH

Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)

Open Release Date: October 27, 2022 Open Date: December 5, 2022 Close Date: September 6, 2025

Purpose...

SBIR

BOTH

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NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required)

Interactive Digital Media (IDM) Biomedical Science Resources for Pre-College Students and Teachers (SBIR) (R43/R44 Clinical Trial Not Allowed)

SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1 Clinical Trial Required)

SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)

Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (U43/U44 Clinical Trials Not Allowed)

Industrialization and Translation of Extracellular Vesicles for use in Regenerative Medicine (UT1/UT2) Clinical Trial Not Allowed

HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)

Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)

Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)